Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
gltAType II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa)    
Predicted Functional Partners:
FP66_01785
Catalyzes the oxidation of malate to oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.994
FP66_07385
Aconitate hydratase; Catalyzes the conversion of citrate to isocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.991
FP66_11900
Catalyzes the formation of fumarate from malate; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.984
FP66_12235
Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.976
aspA
Aspartate ammonia-lyase; Catalyzes the formation of fumarate from aspartate; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.968
FP66_09425
Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.956
gltB
Catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.953
prpB
2-methylisocitrate lyase; Catalyzes the formation of pyruvate and succinate from 2-methylisocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.952
FP66_03395
Malate synthase; Catalyzes the formation of malate from glyoxylate and acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.950
FP66_08060
Phosphoenolpyruvate carboxylase; Catalyzes the formation of oxaloacetate from phosphoenolpyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.946
Your Current Organism:
Halomonas salina
NCBI taxonomy Id: 42565
Other names: ATCC 49509, CIP 106092, DSM 5928, Deleya salina, H. salina, JCM 21221, strain F8-11
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.