Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
FP66_14540GTP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)    
Predicted Functional Partners:
FP66_09835
Riboflavin biosynthesis protein RibD; Derived by automated computational analysis using gene prediction method: Protein Homology.
 0.999
FP66_09840
3,4-dihydroxy-2-butanone 4-phosphate synthase; Bifunctional enzyme DHBP synthase/GTP cyclohydrolase II-like protein; functions in riboflavin synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.997
FP66_12150
Riboflavin synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.
 0.995
FP66_14385
GTP cyclohydrolase; Involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 
 0.973
FP66_09845
6,7-dimethyl-8-ribityllumazine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.969
FP66_08765
Riboflavin synthase subunit beta; RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the ribo [...]
 
 
 0.947
FP66_08225
GTP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.880
FP66_01300
Nucleoside diphosphate kinase; Catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  0.879
FP66_08035
Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.875
FP66_02345
(p)ppGpp synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
  0.867
Your Current Organism:
Halomonas salina
NCBI taxonomy Id: 42565
Other names: ATCC 49509, CIP 106092, DSM 5928, Deleya salina, H. salina, JCM 21221, strain F8-11
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