Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
M446_0200PFAM: AMP-dependent synthetase and ligase; KEGG: mex:Mext_3653 AMP-dependent synthetase and ligase. (566 aa)    
Predicted Functional Partners:
M446_0317
Beta-ketoacyl synthase; PFAM: short-chain dehydrogenase/reductase SDR; phosphopantetheine-binding; Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KR domain protein; Beta-ketoacyl synthase; Acyl transferase; KEGG: mex:Mext_1947 beta-ketoacyl synthase.
  
 0.979
M446_0172
Beta-ketoacyl synthase; PFAM: short-chain dehydrogenase/reductase SDR; phosphopantetheine-binding; Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KR domain protein; Beta-ketoacyl synthase; Acyl transferase; KEGG: sen:SACE_2875 modular polyketide synthase-.
 
 0.965
M446_0170
Beta-ketoacyl synthase; PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; phosphopantetheine-binding; KR domain protein; Beta-ketoacyl synthase; Acyl transferase; KEGG: sen:SACE_2630 modular polyketide synthase.
  
 0.961
M446_6078
PFAM: phosphopantetheine-binding; KEGG: rha:RHA1_ro06664 non-ribosomal peptide synthetase.
  
 
 0.861
M446_3855
PFAM: AMP-dependent synthetase and ligase; KEGG: rsq:Rsph17025_2837 AMP-dependent synthetase and ligase.
  
  
 
0.854
M446_2876
PFAM: AMP-dependent synthetase and ligase; KEGG: nmu:Nmul_A1417 AMP-dependent synthetase and ligase.
 
 
0.835
M446_2308
PFAM: AMP-dependent synthetase and ligase; KEGG: bbt:BBta_5715 putative long-chain-fatty-acid-CoA ligase.
  
 
0.822
M446_3278
PFAM: acyl-CoA dehydrogenase domain protein; KEGG: mex:Mext_3245 acyl-CoA dehydrogenase domain protein.
 
 
 0.702
M446_0201
KEGG: mex:Mext_3652 hypothetical protein.
       0.691
M446_3267
PFAM: NADH dehydrogenase (ubiquinone) 24 kDa subunit; Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; KEGG: mex:Mext_4581 respiratory-chain NADH dehydrogenase domain 51 kDa subunit.
    
 
 0.674
Your Current Organism:
Methylobacterium sp. 446
NCBI taxonomy Id: 426117
Other names: M. sp. 4-46, Methylobacterium sp. 4-46
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