STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
M446_0921PFAM: Forkhead-associated protein; adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: afw:Anae109_3652 putative adenylate/guanylate cyclase. (306 aa)    
Predicted Functional Partners:
M446_2164
KEGG: mex:Mext_1646 2-oxoglutarate dehydrogenase, E1 subunit; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: dehydrogenase E1 component; Transketolase central region.
    
 
 0.857
M446_0913
PFAM: protein kinase; SMART: tyrosine protein kinase; serine/threonine protein kinase; KEGG: bja:blr3604 probable serine/threonine kinase.
 
 
 
 0.832
M446_4670
SMART: serine/threonine protein kinase; leucine-rich repeat-containing protein typical subtype; KEGG: mex:Mext_3080 serine/threonine protein kinase.
   
 
 0.822
M446_6045
PFAM: protein of unknown function DUF692; Xylose isomerase domain protein TIM barrel; KEGG: scl:sce1885 hypothetical protein.
   
    0.795
M446_1526
Multi-sensor hybrid histidine kinase; KEGG: sat:SYN_01077 sensor proteinLuxQ; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein; GAF domain protein.
 
 
 0.784
M446_3321
PAS/PAC sensor hybrid histidine kinase; KEGG: dar:Daro_1934 PAS; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein.
 
 
 0.781
M446_1175
TIGRFAM: general secretion pathway protein D; PFAM: type II and III secretion system protein; NolW domain protein; KEGG: mex:Mext_0031 general secretion pathway protein D.
  
  
 0.777
M446_2024
TIGRFAM: general secretion pathway protein D; PFAM: type II and III secretion system protein; NolW domain protein; KEGG: rpc:RPC_3010 type II and III secretion system protein; Belongs to the bacterial secretin family.
  
  
 0.777
M446_3215
Flagellar motor switch protein FliN; FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. Belongs to the FliN/MopA/SpaO family.
  
 
 0.776
M446_5123
Flagellar motor switch protein FliN; FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. Belongs to the FliN/MopA/SpaO family.
  
 
 0.776
Your Current Organism:
Methylobacterium sp. 446
NCBI taxonomy Id: 426117
Other names: M. sp. 4-46, Methylobacterium sp. 4-46
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.