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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
M446_2000KEGG: bra:BRADO1788 hypothetical protein. (418 aa)    
Predicted Functional Partners:
M446_3102
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
 
 
 0.926
M446_3101
TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mex:Mext_3167 riboflavin synthase, alpha subunit.
 
 
 0.899
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
  
 0.887
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.632
M446_2359
PFAM: bifunctional deaminase-reductase domain protein; KEGG: azc:AZC_4171 putative pyrimidine reductase.
 
 
 0.598
M446_2675
PFAM: ferredoxin; oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: bja:blr7998 putative ferredoxin-NAD reductase component.
 
  
 0.558
M446_1999
KEGG: mex:Mext_2709 hypothetical protein.
       0.519
ribB
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
 
   
 0.456
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
  
  
 0.451
rpmJ
TIGRFAM: ribosomal protein L36; KEGG: mex:Mext_2741 ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family.
   
  
 0.431
Your Current Organism:
Methylobacterium sp. 446
NCBI taxonomy Id: 426117
Other names: M. sp. 4-46, Methylobacterium sp. 4-46
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