Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
M446_2139Two component transcriptional regulator, LuxR family; PFAM: regulatory protein LuxR; response regulator receiver; Sigma-70 region 4 type 2; KEGG: mes:Meso_0596 two component transcriptional regulator, LuxR family. (244 aa)    
Predicted Functional Partners:
M446_5716
Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase dimerisation and phosphoacceptor region; KEGG: ade:Adeh_1998 periplasmic sensor signal transduction histidine kinase.
 
 
 0.879
M446_6780
Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase dimerisation and phosphoacceptor region; KEGG: mex:Mext_4452 ATP-binding region ATPase domain protein.
 
 
 0.862
M446_3321
PAS/PAC sensor hybrid histidine kinase; KEGG: dar:Daro_1934 PAS; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein.
  
 
 0.859
M446_5171
GAF sensor hybrid histidine kinase; PFAM: response regulator receiver; GAF domain protein; ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: ret:RHE_PF00265 probable two-component sensor histidine kinase/response regulator hybrid protein.
  
 
 0.789
M446_0653
Two component transcriptional regulator, LuxR family; PFAM: regulatory protein LuxR; response regulator receiver; KEGG: mex:Mext_4137 response regulator receiver.
  
     0.774
M446_5044
Transcriptional regulator, LuxR family; PFAM: regulatory protein LuxR; KEGG: mex:Mext_1977 regulatory protein LuxR.
  
     0.761
M446_1716
PFAM: regulatory protein LuxR; KEGG: bja:blr7275 transcriptional regulatory protein.
  
     0.751
M446_5358
Multi-sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; Hpt domain protein; KEGG: mex:Mext_3510 ATP-binding region ATPase domain protein.
   
 
 0.689
M446_1526
Multi-sensor hybrid histidine kinase; KEGG: sat:SYN_01077 sensor proteinLuxQ; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein; GAF domain protein.
  
 
 0.667
M446_0247
PAS/PAC sensor hybrid histidine kinase; KEGG: mex:Mext_2842 PAS sensor protein; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein.
   
 
 0.631
Your Current Organism:
Methylobacterium sp. 446
NCBI taxonomy Id: 426117
Other names: M. sp. 4-46, Methylobacterium sp. 4-46
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