node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
M446_2646 | hisA | M446_2646 | M446_6791 | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_1498 tRNA synthetase class II (G H P and S). | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mex:Mext_2551 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.925 |
M446_2646 | hisB | M446_2646 | M446_6794 | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_1498 tRNA synthetase class II (G H P and S). | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mex:Mext_2548 imidazoleglycerol-phosphate dehydratase. | 0.916 |
M446_2646 | hisC | M446_2646 | M446_5257 | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_1498 tRNA synthetase class II (G H P and S). | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: mex:Mext_1593 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.867 |
M446_2646 | hisD | M446_2646 | M446_2638 | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_1498 tRNA synthetase class II (G H P and S). | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.916 |
M446_2646 | hisE | M446_2646 | M446_6789 | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_1498 tRNA synthetase class II (G H P and S). | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: atc:AGR_C_60 phosphoribosyl-ATP pyrophosphohydrolase. | 0.989 |
M446_2646 | hisF | M446_2646 | M446_6790 | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_1498 tRNA synthetase class II (G H P and S). | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.916 |
M446_2646 | hisG | M446_2646 | M446_2645 | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_1498 tRNA synthetase class II (G H P and S). | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.999 |
M446_2646 | hisH | M446_2646 | M446_6792 | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_1498 tRNA synthetase class II (G H P and S). | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.918 |
M446_2646 | hisI | M446_2646 | M446_6319 | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_1498 tRNA synthetase class II (G H P and S). | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.913 |
hisA | M446_2646 | M446_6791 | M446_2646 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mex:Mext_2551 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_1498 tRNA synthetase class II (G H P and S). | 0.925 |
hisA | hisB | M446_6791 | M446_6794 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mex:Mext_2551 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mex:Mext_2548 imidazoleglycerol-phosphate dehydratase. | 0.989 |
hisA | hisC | M446_6791 | M446_5257 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mex:Mext_2551 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: mex:Mext_1593 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.942 |
hisA | hisD | M446_6791 | M446_2638 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mex:Mext_2551 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.980 |
hisA | hisE | M446_6791 | M446_6789 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mex:Mext_2551 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: atc:AGR_C_60 phosphoribosyl-ATP pyrophosphohydrolase. | 0.985 |
hisA | hisF | M446_6791 | M446_6790 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mex:Mext_2551 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.997 |
hisA | hisG | M446_6791 | M446_2645 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mex:Mext_2551 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.970 |
hisA | hisH | M446_6791 | M446_6792 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mex:Mext_2551 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | M446_6791 | M446_6319 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mex:Mext_2551 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisB | M446_2646 | M446_6794 | M446_2646 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mex:Mext_2548 imidazoleglycerol-phosphate dehydratase. | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_1498 tRNA synthetase class II (G H P and S). | 0.916 |
hisB | hisA | M446_6794 | M446_6791 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mex:Mext_2548 imidazoleglycerol-phosphate dehydratase. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mex:Mext_2551 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.989 |