STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
M446_2876PFAM: AMP-dependent synthetase and ligase; KEGG: nmu:Nmul_A1417 AMP-dependent synthetase and ligase. (612 aa)    
Predicted Functional Partners:
M446_2875
PFAM: AMP-dependent synthetase and ligase; phospholipid/glycerol acyltransferase; phosphopantetheine-binding; KEGG: pol:Bpro_3393 AMP-dependent synthetase and ligase.
 
  
0.901
M446_3855
PFAM: AMP-dependent synthetase and ligase; KEGG: rsq:Rsph17025_2837 AMP-dependent synthetase and ligase.
 
 
0.718
M446_0237
PFAM: AMP-dependent synthetase and ligase; KEGG: reh:H16_B1239 long-chain-fatty-acid--CoA ligase.
 
 
0.693
M446_2308
PFAM: AMP-dependent synthetase and ligase; KEGG: bbt:BBta_5715 putative long-chain-fatty-acid-CoA ligase.
  
  
 
0.690
rplE
Ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
    
 
 0.664
M446_0200
PFAM: AMP-dependent synthetase and ligase; KEGG: mex:Mext_3653 AMP-dependent synthetase and ligase.
 
 
0.654
M446_6079
PFAM: AMP-dependent synthetase and ligase; KEGG: scl:sce8262 non-ribosomal peptide synthetase.
 
 
0.650
rplR
Ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
    
 
 0.631
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
    
  0.624
M446_0317
Beta-ketoacyl synthase; PFAM: short-chain dehydrogenase/reductase SDR; phosphopantetheine-binding; Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KR domain protein; Beta-ketoacyl synthase; Acyl transferase; KEGG: mex:Mext_1947 beta-ketoacyl synthase.
  
 
 0.607
Your Current Organism:
Methylobacterium sp. 446
NCBI taxonomy Id: 426117
Other names: M. sp. 4-46, Methylobacterium sp. 4-46
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.