STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
M446_3101TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mex:Mext_3167 riboflavin synthase, alpha subunit. (211 aa)    
Predicted Functional Partners:
ribB
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
 
 0.999
M446_3102
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
  
 0.999
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
 0.998
ribA
GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family.
 
 0.978
M446_2359
PFAM: bifunctional deaminase-reductase domain protein; KEGG: azc:AZC_4171 putative pyrimidine reductase.
 
  
 0.968
M446_2222
TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; KEGG: mex:Mext_0420 riboflavin biosynthesis protein RibF; Belongs to the ribF family.
  
 
 0.943
M446_2550
Acid phosphatase; PFAM: phosphoesterase PA-phosphatase related; KEGG: mex:Mext_1570 acid phosphatase.
    
  0.901
M446_2000
KEGG: bra:BRADO1788 hypothetical protein.
 
 
 0.899
M446_4600
Cyclic nucleotide-binding protein; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: mxa:MXAN_4126 ferredoxin reductase.
  
    0.816
M446_4329
TIGRFAM: ribosomal protein L31; KEGG: mex:Mext_2355 ribosomal protein L31; Belongs to the bacterial ribosomal protein bL31 family.
   
    0.808
Your Current Organism:
Methylobacterium sp. 446
NCBI taxonomy Id: 426117
Other names: M. sp. 4-46, Methylobacterium sp. 4-46
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