STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
M446_3433TIGRFAM: PTS system, sucrose-specific IIBC subunit; PFAM: phosphotransferase system PTS EIIB protein; phosphotransferase system EIIC; KEGG: rso:RSp1285 probable PTS system, sucrose-specific (IIBC component) transmembrane protein. (462 aa)    
Predicted Functional Partners:
M446_3431
TIGRFAM: PTS system, glucose subfamily, IIA subunit; PFAM: sugar-specific permease EIIA 1 domain; KEGG: ccr:CC_0537 PTS system, fructose-specific EIIA/HPr/EI components.
 
 0.998
M446_3432
Sucrose-6-phosphate hydrolase; Enables the bacterium to metabolize sucrose as a sole carbon source; Belongs to the glycosyl hydrolase 32 family.
 
 
 0.995
M446_3430
Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
 
 
 0.971
M446_0229
TIGRFAM: phosphocarrier, HPr family; PFAM: phosphocarrier HPr protein; KEGG: mex:Mext_1234 phosphocarrier, HPr family.
 
 
 0.943
M446_0859
KEGG: bra:BRADO0437 conserved hypothetical protein; putative glucokinase.
  
 
 0.762
M446_2191
TIGRFAM: PTS IIA-like nitrogen-regulatory protein PtsN; PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2; KEGG: mex:Mext_2503 PTS IIA-like nitrogen-regulatory protein PtsN.
  
  
 0.762
M446_2296
PFAM: ROK family protein; KEGG: mex:Mext_2323 ROK family protein.
  
 
 0.762
M446_3434
Transcriptional regulator, LacI family; PFAM: regulatory protein LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: rso:RSp1286 putative DNA-binding sucrose operon transcriptional repressor transcription regulator protein.
 
   
 0.706
M446_0496
PFAM: sugar isomerase (SIS); KEGG: mex:Mext_4327 sugar isomerase (SIS).
 
  
 0.557
M446_0228
PFAM: PTS system fructose subfamily IIA component; KEGG: mex:Mext_1235 PTS system fructose subfamily IIA component.
  
  
 0.544
Your Current Organism:
Methylobacterium sp. 446
NCBI taxonomy Id: 426117
Other names: M. sp. 4-46, Methylobacterium sp. 4-46
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