M446_5406 protein (Methylobacterium sp. 446)

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M446_5406

PFAM: DNA polymerase III chi subunit HolC; KEGG: mex:Mext_4656 DNA polymerase III chi subunit HolC. (150 aa)

Predicted Functional Partners:

M446_1406

0.841

M446_4448

0.837

M446_0002

0.819

dnaX

0.809

M446_6279

0.805

dnaE2

0.784

M446_5992

0.784

M446_1507

0.763

recO

0.758

M446_2064

0.691

Your Current Organism:

Methylobacterium sp. 446

NCBI taxonomy Id: 426117
Other names: M. sp. 4-46, Methylobacterium sp. 4-46

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
M446_0002	M446_1406	M446_0002	M446_1406	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: mex:Mext_1587 DNA polymerase III, delta subunit.	0.902
M446_0002	M446_1507	M446_0002	M446_1507	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	KEGG: aae:aq_1855 DNA polymerase III gamma subunit; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase.	0.784
M446_0002	M446_4448	M446_0002	M446_4448	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	0.777
M446_0002	M446_5406	M446_0002	M446_5406	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	PFAM: DNA polymerase III chi subunit HolC; KEGG: mex:Mext_4656 DNA polymerase III chi subunit HolC.	0.819
M446_0002	M446_5992	M446_0002	M446_5992	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	KEGG: mex:Mext_1048 DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; DNA polymerase III alpha subunit; SMART: phosphoesterase PHP domain protein.	0.841
M446_0002	M446_6279	M446_0002	M446_6279	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	KEGG: mex:Mext_4190 DNA-directed DNA polymerase.	0.842
M446_0002	dnaE2	M446_0002	M446_4496	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.	0.784
M446_0002	dnaX	M446_0002	M446_4243	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.880
M446_0002	recO	M446_0002	M446_4316	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination.	0.628
M446_1406	M446_0002	M446_1406	M446_0002	TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: mex:Mext_1587 DNA polymerase III, delta subunit.	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.902
M446_1406	M446_1507	M446_1406	M446_1507	TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: mex:Mext_1587 DNA polymerase III, delta subunit.	KEGG: aae:aq_1855 DNA polymerase III gamma subunit; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase.	0.787
M446_1406	M446_5406	M446_1406	M446_5406	TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: mex:Mext_1587 DNA polymerase III, delta subunit.	PFAM: DNA polymerase III chi subunit HolC; KEGG: mex:Mext_4656 DNA polymerase III chi subunit HolC.	0.841
M446_1406	M446_5992	M446_1406	M446_5992	TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: mex:Mext_1587 DNA polymerase III, delta subunit.	KEGG: mex:Mext_1048 DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; DNA polymerase III alpha subunit; SMART: phosphoesterase PHP domain protein.	0.808
M446_1406	M446_6279	M446_1406	M446_6279	TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: mex:Mext_1587 DNA polymerase III, delta subunit.	KEGG: mex:Mext_4190 DNA-directed DNA polymerase.	0.822
M446_1406	dnaE2	M446_1406	M446_4496	TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: mex:Mext_1587 DNA polymerase III, delta subunit.	DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.	0.808
M446_1406	dnaX	M446_1406	M446_4243	TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: mex:Mext_1587 DNA polymerase III, delta subunit.	DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.828
M446_1406	recO	M446_1406	M446_4316	TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: mex:Mext_1587 DNA polymerase III, delta subunit.	DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination.	0.597
M446_1507	M446_0002	M446_1507	M446_0002	KEGG: aae:aq_1855 DNA polymerase III gamma subunit; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase.	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.784
M446_1507	M446_1406	M446_1507	M446_1406	KEGG: aae:aq_1855 DNA polymerase III gamma subunit; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase.	TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: mex:Mext_1587 DNA polymerase III, delta subunit.	0.787
M446_1507	M446_4448	M446_1507	M446_4448	KEGG: aae:aq_1855 DNA polymerase III gamma subunit; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase.	Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	0.768