STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
M446_6563PFAM: Stage II sporulation E family protein; SMART: protein phosphatase 2C domain protein; KEGG: xcv:XCV1322 hypothetical protein. (197 aa)    
Predicted Functional Partners:
M446_6564
Putative anti-sigma regulatory factor, serine/threonine protein kinase; PFAM: ATP-binding region ATPase domain protein; KEGG: nfa:nfa32130 putative sigma activity regulating kinase.
 
 
 0.992
M446_6565
Putative anti-sigma regulatory factor, serine/threonine protein kinase; PFAM: ATP-binding region ATPase domain protein; KEGG: nfa:nfa32130 putative sigma activity regulating kinase.
 
 
 0.992
M446_6566
KEGG: rca:Rcas_0676 anti-sigma-factor antagonist.
 
 
 0.990
M446_6567
PFAM: Sulfate transporter/antisigma-factor antagonist STAS; KEGG: fal:FRAAL1275 positive regulator of sigma-B.
 
 
 0.990
M446_3321
PAS/PAC sensor hybrid histidine kinase; KEGG: dar:Daro_1934 PAS; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein.
  
  
 0.910
M446_5358
Multi-sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; Hpt domain protein; KEGG: mex:Mext_3510 ATP-binding region ATPase domain protein.
  
  
 0.895
M446_4933
PFAM: protein of unknown function DUF140; KEGG: mex:Mext_0891 protein of unknown function DUF140.
  
 
 0.859
M446_5171
GAF sensor hybrid histidine kinase; PFAM: response regulator receiver; GAF domain protein; ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: ret:RHE_PF00265 probable two-component sensor histidine kinase/response regulator hybrid protein.
 
  
 0.833
M446_4189
KEGG: mex:Mext_3042 hypothetical protein.
   
    0.801
M446_6518
KEGG: mex:Mext_0693 hypothetical protein.
   
    0.801
Your Current Organism:
Methylobacterium sp. 446
NCBI taxonomy Id: 426117
Other names: M. sp. 4-46, Methylobacterium sp. 4-46
Server load: medium (52%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.