node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACB23471.1 | ACB26259.1 | Mrad2831_1476 | Mrad2831_4292 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; KEGG: mex:Mext_4725 L-threonine-O-3-phosphate decarboxylase. | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_1498 tRNA synthetase class II (G H P and S). | 0.859 |
ACB23471.1 | hisA | Mrad2831_1476 | Mrad2831_0470 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; KEGG: mex:Mext_4725 L-threonine-O-3-phosphate decarboxylase. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mex:Mext_2551 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.882 |
ACB23471.1 | hisB | Mrad2831_1476 | Mrad2831_0467 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; KEGG: mex:Mext_4725 L-threonine-O-3-phosphate decarboxylase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mex:Mext_2548 imidazoleglycerol-phosphate dehydratase. | 0.885 |
ACB23471.1 | hisD | Mrad2831_1476 | Mrad2831_3512 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; KEGG: mex:Mext_4725 L-threonine-O-3-phosphate decarboxylase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.892 |
ACB23471.1 | hisE | Mrad2831_1476 | Mrad2831_1011 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; KEGG: mex:Mext_4725 L-threonine-O-3-phosphate decarboxylase. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mex:Mext_2553 phosphoribosyl-ATP diphosphatase. | 0.885 |
ACB23471.1 | hisF | Mrad2831_1476 | Mrad2831_0471 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; KEGG: mex:Mext_4725 L-threonine-O-3-phosphate decarboxylase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.886 |
ACB23471.1 | hisG | Mrad2831_1476 | Mrad2831_4293 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; KEGG: mex:Mext_4725 L-threonine-O-3-phosphate decarboxylase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.863 |
ACB23471.1 | hisH | Mrad2831_1476 | Mrad2831_0469 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; KEGG: mex:Mext_4725 L-threonine-O-3-phosphate decarboxylase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.888 |
ACB23471.1 | hisI | Mrad2831_1476 | Mrad2831_4638 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; KEGG: mex:Mext_4725 L-threonine-O-3-phosphate decarboxylase. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.887 |
ACB26259.1 | ACB23471.1 | Mrad2831_4292 | Mrad2831_1476 | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_1498 tRNA synthetase class II (G H P and S). | TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; KEGG: mex:Mext_4725 L-threonine-O-3-phosphate decarboxylase. | 0.859 |
ACB26259.1 | hisA | Mrad2831_4292 | Mrad2831_0470 | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_1498 tRNA synthetase class II (G H P and S). | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mex:Mext_2551 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.894 |
ACB26259.1 | hisB | Mrad2831_4292 | Mrad2831_0467 | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_1498 tRNA synthetase class II (G H P and S). | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mex:Mext_2548 imidazoleglycerol-phosphate dehydratase. | 0.918 |
ACB26259.1 | hisC | Mrad2831_4292 | Mrad2831_1875 | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_1498 tRNA synthetase class II (G H P and S). | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: mex:Mext_1593 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.859 |
ACB26259.1 | hisD | Mrad2831_4292 | Mrad2831_3512 | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_1498 tRNA synthetase class II (G H P and S). | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.911 |
ACB26259.1 | hisE | Mrad2831_4292 | Mrad2831_1011 | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_1498 tRNA synthetase class II (G H P and S). | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mex:Mext_2553 phosphoribosyl-ATP diphosphatase. | 0.987 |
ACB26259.1 | hisF | Mrad2831_4292 | Mrad2831_0471 | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_1498 tRNA synthetase class II (G H P and S). | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.908 |
ACB26259.1 | hisG | Mrad2831_4292 | Mrad2831_4293 | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_1498 tRNA synthetase class II (G H P and S). | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.999 |
ACB26259.1 | hisH | Mrad2831_4292 | Mrad2831_0469 | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_1498 tRNA synthetase class II (G H P and S). | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.886 |
ACB26259.1 | hisI | Mrad2831_4292 | Mrad2831_4638 | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_1498 tRNA synthetase class II (G H P and S). | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.892 |
hisA | ACB23471.1 | Mrad2831_0470 | Mrad2831_1476 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mex:Mext_2551 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; KEGG: mex:Mext_4725 L-threonine-O-3-phosphate decarboxylase. | 0.882 |