node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACB24867.1 | ACB25933.1 | Mrad2831_2883 | Mrad2831_3959 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: mex:Mext_4269 bifunctional deaminase-reductase domain protein. | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mex:Mext_3167 riboflavin synthase, alpha subunit. | 0.860 |
ACB24867.1 | guaB | Mrad2831_2883 | Mrad2831_0084 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: mex:Mext_4269 bifunctional deaminase-reductase domain protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.522 |
ACB24867.1 | ribB | Mrad2831_2883 | Mrad2831_2755 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: mex:Mext_4269 bifunctional deaminase-reductase domain protein. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.930 |
ACB24867.1 | ribH | Mrad2831_2883 | Mrad2831_3980 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: mex:Mext_4269 bifunctional deaminase-reductase domain protein. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.744 |
ACB25932.1 | ACB25933.1 | Mrad2831_3958 | Mrad2831_3959 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mex:Mext_3167 riboflavin synthase, alpha subunit. | 0.999 |
ACB25932.1 | folE | Mrad2831_3958 | Mrad2831_4639 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | PFAM: GTP cyclohydrolase I; KEGG: mex:Mext_2265 GTP cyclohydrolase I. | 0.606 |
ACB25932.1 | guaB | Mrad2831_3958 | Mrad2831_0084 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.670 |
ACB25932.1 | moaA | Mrad2831_3958 | Mrad2831_2586 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | 0.466 |
ACB25932.1 | moaA-2 | Mrad2831_3958 | Mrad2831_3898 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | 0.466 |
ACB25932.1 | ndk | Mrad2831_3958 | Mrad2831_0488 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.458 |
ACB25932.1 | ribB | Mrad2831_3958 | Mrad2831_2755 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.999 |
ACB25932.1 | ribH | Mrad2831_3958 | Mrad2831_3980 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.984 |
ACB25933.1 | ACB24867.1 | Mrad2831_3959 | Mrad2831_2883 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mex:Mext_3167 riboflavin synthase, alpha subunit. | PFAM: bifunctional deaminase-reductase domain protein; KEGG: mex:Mext_4269 bifunctional deaminase-reductase domain protein. | 0.860 |
ACB25933.1 | ACB25932.1 | Mrad2831_3959 | Mrad2831_3958 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mex:Mext_3167 riboflavin synthase, alpha subunit. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.999 |
ACB25933.1 | ribB | Mrad2831_3959 | Mrad2831_2755 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mex:Mext_3167 riboflavin synthase, alpha subunit. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.999 |
ACB25933.1 | ribH | Mrad2831_3959 | Mrad2831_3980 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mex:Mext_3167 riboflavin synthase, alpha subunit. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.998 |
ACB26383.1 | folE | Mrad2831_4417 | Mrad2831_4639 | PFAM: ferredoxin; adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: mex:Mext_3083 adenylyl cyclase class-3/4/guanylyl cyclase. | PFAM: GTP cyclohydrolase I; KEGG: mex:Mext_2265 GTP cyclohydrolase I. | 0.803 |
ACB26383.1 | moaA | Mrad2831_4417 | Mrad2831_2586 | PFAM: ferredoxin; adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: mex:Mext_3083 adenylyl cyclase class-3/4/guanylyl cyclase. | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | 0.665 |
ACB26383.1 | moaA-2 | Mrad2831_4417 | Mrad2831_3898 | PFAM: ferredoxin; adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: mex:Mext_3083 adenylyl cyclase class-3/4/guanylyl cyclase. | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | 0.665 |
ACB26383.1 | ndk | Mrad2831_4417 | Mrad2831_0488 | PFAM: ferredoxin; adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: mex:Mext_3083 adenylyl cyclase class-3/4/guanylyl cyclase. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.923 |