node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NCS6 | PTRG_00633 | B2VY78 | B2VS58 | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. | Eukaryotic translation initiation factor 3, gamma subunit. | 0.690 |
NCS6 | PTRG_02231 | B2VY78 | B2VV48 | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. | ATP-dependent RNA helicase DBP9. | 0.814 |
NCS6 | PTRG_06871 | B2VY78 | B2WB59 | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. | Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. | 0.455 |
NCS6 | PTRG_11573 | B2VY78 | B2WNL3 | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. | ATP-dependent RNA helicase DBP3; Belongs to the DEAD box helicase family. | 0.450 |
NCS6 | SPB1 | B2VY78 | B2WIP3 | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. | AdoMet-dependent rRNA methyltransferase SPB1; Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. | 0.849 |
NCS6 | ncs2 | B2VY78 | B2W6W8 | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. | Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ncs6 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. | 0.995 |
PTRG_00134 | PTRG_11573 | B2VRF3 | B2WNL3 | Beta-Ala-His dipeptidase. | ATP-dependent RNA helicase DBP3; Belongs to the DEAD box helicase family. | 0.485 |
PTRG_00134 | ncs2 | B2VRF3 | B2W6W8 | Beta-Ala-His dipeptidase. | Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ncs6 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. | 0.794 |
PTRG_00633 | NCS6 | B2VS58 | B2VY78 | Eukaryotic translation initiation factor 3, gamma subunit. | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. | 0.690 |
PTRG_00633 | PTRG_00690 | B2VS58 | B2VSI6 | Eukaryotic translation initiation factor 3, gamma subunit. | tRNA(Ile)-lysidine synthase (TRNA(Ile)-lysidine synthetase). | 0.479 |
PTRG_00633 | PTRG_02231 | B2VS58 | B2VV48 | Eukaryotic translation initiation factor 3, gamma subunit. | ATP-dependent RNA helicase DBP9. | 0.847 |
PTRG_00633 | PTRG_06871 | B2VS58 | B2WB59 | Eukaryotic translation initiation factor 3, gamma subunit. | Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. | 0.717 |
PTRG_00633 | PTRG_11573 | B2VS58 | B2WNL3 | Eukaryotic translation initiation factor 3, gamma subunit. | ATP-dependent RNA helicase DBP3; Belongs to the DEAD box helicase family. | 0.848 |
PTRG_00633 | SPB1 | B2VS58 | B2WIP3 | Eukaryotic translation initiation factor 3, gamma subunit. | AdoMet-dependent rRNA methyltransferase SPB1; Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. | 0.893 |
PTRG_00633 | ncs2 | B2VS58 | B2W6W8 | Eukaryotic translation initiation factor 3, gamma subunit. | Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ncs6 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. | 0.789 |
PTRG_00633 | ytm1 | B2VS58 | B2VZH2 | Eukaryotic translation initiation factor 3, gamma subunit. | Ribosome biogenesis protein ytm1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. | 0.865 |
PTRG_00690 | PTRG_00633 | B2VSI6 | B2VS58 | tRNA(Ile)-lysidine synthase (TRNA(Ile)-lysidine synthetase). | Eukaryotic translation initiation factor 3, gamma subunit. | 0.479 |
PTRG_00690 | ncs2 | B2VSI6 | B2W6W8 | tRNA(Ile)-lysidine synthase (TRNA(Ile)-lysidine synthetase). | Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ncs6 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. | 0.968 |
PTRG_02231 | NCS6 | B2VV48 | B2VY78 | ATP-dependent RNA helicase DBP9. | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. | 0.814 |
PTRG_02231 | PTRG_00633 | B2VV48 | B2VS58 | ATP-dependent RNA helicase DBP9. | Eukaryotic translation initiation factor 3, gamma subunit. | 0.847 |