node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDJ81732.1 | SDK53875.1 | SAMN04488098_10059 | SAMN04488098_10379 | Dihydrolipoamide dehydrogenase. | Glutamate dehydrogenase (NAD(P)+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.901 |
SDJ81732.1 | SDK57591.1 | SAMN04488098_10059 | SAMN04488098_10403 | Dihydrolipoamide dehydrogenase. | Glycine cleavage system H protein. | 0.912 |
SDJ81732.1 | folD | SAMN04488098_10059 | SAMN04488098_100831 | Dihydrolipoamide dehydrogenase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.676 |
SDJ81732.1 | gcvH | SAMN04488098_10059 | SAMN04488098_10623 | Dihydrolipoamide dehydrogenase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.922 |
SDJ81732.1 | gcvPA | SAMN04488098_10059 | SAMN04488098_10622 | Dihydrolipoamide dehydrogenase. | Glycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.905 |
SDJ81732.1 | gcvPB | SAMN04488098_10059 | SAMN04488098_10621 | Dihydrolipoamide dehydrogenase. | Glycine dehydrogenase subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.906 |
SDJ81732.1 | gcvT | SAMN04488098_10059 | SAMN04488098_10624 | Dihydrolipoamide dehydrogenase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.914 |
SDJ81732.1 | glyA | SAMN04488098_10059 | SAMN04488098_104215 | Dihydrolipoamide dehydrogenase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.894 |
SDJ81732.1 | lipL | SAMN04488098_10059 | SAMN04488098_100822 | Dihydrolipoamide dehydrogenase. | octanoyl-[GcvH]:protein N-octanoyltransferase; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. | 0.457 |
SDJ81732.1 | purQ | SAMN04488098_10059 | SAMN04488098_100412 | Dihydrolipoamide dehydrogenase. | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] | 0.881 |
SDK53875.1 | SDJ81732.1 | SAMN04488098_10379 | SAMN04488098_10059 | Glutamate dehydrogenase (NAD(P)+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Dihydrolipoamide dehydrogenase. | 0.901 |
SDK53875.1 | SDK57591.1 | SAMN04488098_10379 | SAMN04488098_10403 | Glutamate dehydrogenase (NAD(P)+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glycine cleavage system H protein. | 0.882 |
SDK53875.1 | gcvH | SAMN04488098_10379 | SAMN04488098_10623 | Glutamate dehydrogenase (NAD(P)+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.882 |
SDK53875.1 | gcvPA | SAMN04488098_10379 | SAMN04488098_10622 | Glutamate dehydrogenase (NAD(P)+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.880 |
SDK53875.1 | gcvPB | SAMN04488098_10379 | SAMN04488098_10621 | Glutamate dehydrogenase (NAD(P)+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glycine dehydrogenase subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.900 |
SDK53875.1 | glyA | SAMN04488098_10379 | SAMN04488098_104215 | Glutamate dehydrogenase (NAD(P)+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.492 |
SDK53875.1 | purQ | SAMN04488098_10379 | SAMN04488098_100412 | Glutamate dehydrogenase (NAD(P)+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] | 0.884 |
SDK57591.1 | SDJ81732.1 | SAMN04488098_10403 | SAMN04488098_10059 | Glycine cleavage system H protein. | Dihydrolipoamide dehydrogenase. | 0.912 |
SDK57591.1 | SDK53875.1 | SAMN04488098_10403 | SAMN04488098_10379 | Glycine cleavage system H protein. | Glutamate dehydrogenase (NAD(P)+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.882 |
SDK57591.1 | folD | SAMN04488098_10403 | SAMN04488098_100831 | Glycine cleavage system H protein. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.908 |