node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SEK67527.1 | SEK67603.1 | SAMN04488099_10529 | SAMN04488099_10531 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Formiminotetrahydrofolate cyclodeaminase. | 0.813 |
SEK67527.1 | fhs | SAMN04488099_10529 | SAMN04488099_10532 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.824 |
SEK67527.1 | folD | SAMN04488099_10529 | SAMN04488099_10530 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.983 |
SEK67527.1 | glyA | SAMN04488099_10529 | SAMN04488099_105169 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.405 |
SEK67527.1 | purD | SAMN04488099_10529 | SAMN04488099_10575 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.483 |
SEK67527.1 | purH | SAMN04488099_10529 | SAMN04488099_10576 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.562 |
SEK67527.1 | purN | SAMN04488099_10529 | SAMN04488099_10577 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.820 |
SEK67603.1 | SEK67527.1 | SAMN04488099_10531 | SAMN04488099_10529 | Formiminotetrahydrofolate cyclodeaminase. | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.813 |
SEK67603.1 | SEK75979.1 | SAMN04488099_10531 | SAMN04488099_1069 | Formiminotetrahydrofolate cyclodeaminase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.478 |
SEK67603.1 | fhs | SAMN04488099_10531 | SAMN04488099_10532 | Formiminotetrahydrofolate cyclodeaminase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.974 |
SEK67603.1 | folD | SAMN04488099_10531 | SAMN04488099_10530 | Formiminotetrahydrofolate cyclodeaminase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.941 |
SEK67603.1 | gcvT | SAMN04488099_10531 | SAMN04488099_1204 | Formiminotetrahydrofolate cyclodeaminase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.848 |
SEK67603.1 | glyA | SAMN04488099_10531 | SAMN04488099_105169 | Formiminotetrahydrofolate cyclodeaminase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.531 |
SEK67603.1 | purD | SAMN04488099_10531 | SAMN04488099_10575 | Formiminotetrahydrofolate cyclodeaminase. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.504 |
SEK67603.1 | purH | SAMN04488099_10531 | SAMN04488099_10576 | Formiminotetrahydrofolate cyclodeaminase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.806 |
SEK67603.1 | purN | SAMN04488099_10531 | SAMN04488099_10577 | Formiminotetrahydrofolate cyclodeaminase. | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.815 |
SEK75979.1 | SEK67603.1 | SAMN04488099_1069 | SAMN04488099_10531 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formiminotetrahydrofolate cyclodeaminase. | 0.478 |
SEK75979.1 | fhs | SAMN04488099_1069 | SAMN04488099_10532 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.904 |
SEK75979.1 | folD | SAMN04488099_1069 | SAMN04488099_10530 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.616 |
SEK75979.1 | gcvT | SAMN04488099_1069 | SAMN04488099_1204 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.893 |