STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (255 aa)    
Predicted Functional Partners:
SDE45827.1
Sulfur carrier protein.
 
 0.999
SDE45850.1
Thiazole tautomerase (transcriptional regulator TenI).
 
 
 0.997
SDE75543.1
D-amino-acid dehydrogenase.
 
 0.993
SDE45775.1
Adenylyltransferase and sulfurtransferase.
 
 0.982
SDD75947.1
Adenylyltransferase and sulfurtransferase.
 
 0.943
thiE
Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 
 0.942
thiI
Thiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
     
 0.931
dxs
1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
     
 0.931
SDD76143.1
Molybdopterin synthase sulfur carrier subunit.
   
 0.875
SDD79837.1
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase.
 
 
 0.868
Your Current Organism:
Bhargavaea beijingensis
NCBI taxonomy Id: 426756
Other names: B. beijingensis, Bacillus beijingensis, Bacillus beijingensis Qiu et al. 2009, Bacillus sp. ge09, Bacillus sp. ge10, Bhargavaea beijingensis (Qiu et al. 2009) Verma et al. 2012, CGMCC 1.6762, DSM 19037, strain ge10
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