STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDS76054.1CoA binding domain protein; KEGG: pub:SAR11_1259 2.0e-07 met17; unknown CoA binding protein; COG: COG1832 Predicted CoA-binding protein. (137 aa)    
Predicted Functional Partners:
ilvA
Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
    
  0.864
EDS75105.1
KEGG: ctc:CTC01806 2.7e-209 5-methyltetrahydrofolate--homocysteine methyltransferase K00548; COG: COG1410 Methionine synthase I, cobalamin-binding domain; Psort location: Cytoplasmic, score: 8.87.
    
  0.850
EDS74130.1
O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; KEGG: gka:GK0284 6.0e-118 O-acetylhomoserine sulfhydrylase K01740; COG: COG2873 O-acetylhomoserine sulfhydrylase; Psort location: Cytoplasmic, score: 9.98.
    
  0.628
EDS76055.1
Amidohydrolase family protein; KEGG: hma:rrnAC3411 1.1e-21 metal dependent amidohydrolase superfamily protein K01443:K01427:K01465:K01486; COG: COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold.
       0.614
EDS75907.1
Transcriptional regulator, Fur family; COG: COG0735 Fe2+/Zn2+ uptake regulation proteins; Psort location: Cytoplasmic, score: 8.87; Belongs to the Fur family.
  
    0.609
cysK
Cysteine synthase A; KEGG: cno:NT01CX_0572 1.6e-92 cysK; cysteine synthase A K01738; COG: COG0031 Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.
    
 0.597
metA
Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.
    
  0.595
luxS
S-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
    
  0.593
EDS73674.1
DNA-binding helix-turn-helix protein; KEGG: mmo:MMOB3450 0.00011 dam; adenine-specific DNA methyltransferase K06223; COG: COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases); Psort location: Cytoplasmic, score: 8.87.
    
  0.592
metF
KEGG: mxa:MXAN_3039 1.4e-61 metF; 5,10-methylenetetrahydrofolate reductase; COG: COG0685 5,10-methylenetetrahydrofolate reductase; Psort location: Cytoplasmic, score: 8.87.
    
  0.589
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.