node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EDS74002.1 | xth | CLOSPI_02428 | CLOSPI_00022 | Transcriptional regulator, Spx/MgsR family; KEGG: fnu:FN0052 7.1e-28 arsenate reductase; COG: COG1393 Arsenate reductase and related proteins, glutaredoxin family; Psort location: Cytoplasmic, score: 8.87; Belongs to the ArsC family. | Exodeoxyribonuclease III; KEGG: cac:CAC0222 1.2e-96 exoA; exodeoxyribonuclease (exoA) K01142; COG: COG0708 Exonuclease III; Psort location: Cytoplasmic, score: 9.98. | 0.762 |
EDS74331.1 | polA | CLOSPI_01915 | CLOSPI_00138 | Hypothetical protein; KEGG: reh:H16_A2653 2.3e-15 G:T/U mismatch-specific DNA glycosylase K01249; COG: COG3663 G:T/U mismatch-specific DNA glycosylase. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.411 |
EDS74331.1 | xth | CLOSPI_01915 | CLOSPI_00022 | Hypothetical protein; KEGG: reh:H16_A2653 2.3e-15 G:T/U mismatch-specific DNA glycosylase K01249; COG: COG3663 G:T/U mismatch-specific DNA glycosylase. | Exodeoxyribonuclease III; KEGG: cac:CAC0222 1.2e-96 exoA; exodeoxyribonuclease (exoA) K01142; COG: COG0708 Exonuclease III; Psort location: Cytoplasmic, score: 9.98. | 0.894 |
EDS74902.1 | xth | CLOSPI_01217 | CLOSPI_00022 | Pseudouridylate synthase; KEGG: tte:TTE0052 1.1e-61 rsuA; 16S rRNA uridine-516 pseudouridylate synthase and related Pseudouridylate synthase K06183; COG: COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Psort location: Cytoplasmic, score: 8.87; Belongs to the pseudouridine synthase RsuA family. | Exodeoxyribonuclease III; KEGG: cac:CAC0222 1.2e-96 exoA; exodeoxyribonuclease (exoA) K01142; COG: COG0708 Exonuclease III; Psort location: Cytoplasmic, score: 9.98. | 0.640 |
birA | tadA | CLOSPI_00391 | CLOSPI_02401 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Cytidine and deoxycytidylate deaminase zinc-binding region; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.954 |
birA | xth | CLOSPI_00391 | CLOSPI_00022 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Exodeoxyribonuclease III; KEGG: cac:CAC0222 1.2e-96 exoA; exodeoxyribonuclease (exoA) K01142; COG: COG0708 Exonuclease III; Psort location: Cytoplasmic, score: 9.98. | 0.797 |
dnaN | polA | CLOSPI_02412 | CLOSPI_00138 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.999 |
dnaN | ung | CLOSPI_02412 | CLOSPI_01657 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.758 |
dnaN | xth | CLOSPI_02412 | CLOSPI_00022 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Exodeoxyribonuclease III; KEGG: cac:CAC0222 1.2e-96 exoA; exodeoxyribonuclease (exoA) K01142; COG: COG0708 Exonuclease III; Psort location: Cytoplasmic, score: 9.98. | 0.996 |
nfo | nth | CLOSPI_01871 | CLOSPI_01384 | Apurinic endonuclease (APN1); Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.778 |
nfo | polA | CLOSPI_01871 | CLOSPI_00138 | Apurinic endonuclease (APN1); Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.462 |
nfo | ung | CLOSPI_01871 | CLOSPI_01657 | Apurinic endonuclease (APN1); Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. | uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.600 |
nfo | xth | CLOSPI_01871 | CLOSPI_00022 | Apurinic endonuclease (APN1); Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. | Exodeoxyribonuclease III; KEGG: cac:CAC0222 1.2e-96 exoA; exodeoxyribonuclease (exoA) K01142; COG: COG0708 Exonuclease III; Psort location: Cytoplasmic, score: 9.98. | 0.958 |
nth | nfo | CLOSPI_01384 | CLOSPI_01871 | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | Apurinic endonuclease (APN1); Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. | 0.778 |
nth | polA | CLOSPI_01384 | CLOSPI_00138 | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.775 |
nth | ung | CLOSPI_01384 | CLOSPI_01657 | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.851 |
nth | xth | CLOSPI_01384 | CLOSPI_00022 | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | Exodeoxyribonuclease III; KEGG: cac:CAC0222 1.2e-96 exoA; exodeoxyribonuclease (exoA) K01142; COG: COG0708 Exonuclease III; Psort location: Cytoplasmic, score: 9.98. | 0.999 |
polA | EDS74331.1 | CLOSPI_00138 | CLOSPI_01915 | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | Hypothetical protein; KEGG: reh:H16_A2653 2.3e-15 G:T/U mismatch-specific DNA glycosylase K01249; COG: COG3663 G:T/U mismatch-specific DNA glycosylase. | 0.411 |
polA | dnaN | CLOSPI_00138 | CLOSPI_02412 | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.999 |
polA | nfo | CLOSPI_00138 | CLOSPI_01871 | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | Apurinic endonuclease (APN1); Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. | 0.462 |