STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa)    
Predicted Functional Partners:
trpC
KEGG: cac:CAC3160 2.3e-52 trpC; indole-3-glycerol phosphate synthase K01609; COG: COG0134 Indole-3-glycerol phosphate synthase; Belongs to the TrpC family.
 
 0.999
trpF
KEGG: cac:CAC3159 2.2e-40 trpF; phosphoribosylanthranilate isomerase K01817; COG: COG0135 Phosphoribosylanthranilate isomerase; Belongs to the TrpF family.
 
 0.999
trpA
Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 0.999
trpC-2
KEGG: chy:CHY_1584 6.0e-47 trpC; indole-3-glycerol phosphate synthase K01609; COG: COG0134 Indole-3-glycerol phosphate synthase; Psort location: Cytoplasmic, score: 8.87; Belongs to the TrpC family.
 
 0.999
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
 0.996
EDS76069.1
Glutamine amidotransferase, class I; KEGG: tte:TTE1582 3.1e-57 pabA; anthranilate/para-aminobenzoate synthases component II K01658; COG: COG0512 Anthranilate/para-aminobenzoate synthases component II; Psort location: Cytoplasmic, score: 8.87.
 
 0.988
EDS76068.1
Chorismate binding enzyme; KEGG: aae:aq_582 1.8e-100 trpE; anthranilate synthase component I K01657; COG: COG0147 Anthranilate/para-aminobenzoate synthases component I; Psort location: Cytoplasmic, score: 8.87.
 
  
 0.969
ilvA
Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 0.908
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.874
metA
Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.
    
  0.850
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.