STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDS76099.1Putative YigZ family protein; KEGG: spi:MGAS10750_Spy1437 6.8e-30 Xaa-Pro dipeptidase K01271; COG: COG1739 Uncharacterized conserved protein; Psort location: Cytoplasmic, score: 8.87. (199 aa)    
Predicted Functional Partners:
EDS76100.1
dUTP diphosphatase; COG: COG4508 Uncharacterized protein conserved in bacteria.
       0.615
EDS76098.1
EDD domain protein, DegV family; COG: COG1307 Uncharacterized protein conserved in bacteria; Psort location: Cytoplasmic, score: 8.87.
       0.567
luxS
S-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
       0.546
EDS74211.1
NOL1/NOP2/sun family protein; KEGG: spa:M6_Spy0946 4.3e-76 putative 23S rRNA m(5)C methyltransferase K00599; COG: COG3270 Uncharacterized conserved protein; Psort location: Cytoplasmic, score: 8.87.
  
  
 0.537
cysK
Cysteine synthase A; KEGG: cno:NT01CX_0572 1.6e-92 cysK; cysteine synthase A K01738; COG: COG0031 Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.
   
   0.478
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
   
   0.473
EDS74281.1
Hypothetical protein; COG: COG2384 Predicted SAM-dependent methyltransferase.
   
    0.454
groL
Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
    
   0.446
purB
KEGG: vfi:VF1786 1.4e-109 adenylosuccinate lyase K01756; COG: COG0015 Adenylosuccinate lyase; Psort location: Cytoplasmic, score: 8.87.
 
     0.418
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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