STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDS76024.1KEGG: btk:BT9727_4333 1.5e-215 dnaE; DNA polymerase III, alpha subunit K02337; COG: COG0587 DNA polymerase III, alpha subunit; Psort location: Cytoplasmic, score: 9.98. (1017 aa)    
Predicted Functional Partners:
dnaN
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 
 0.992
holA
DNA polymerase III, delta subunit; KEGG: bld:BLi02748 5.4e-46 yqeN; similar to proteins; RBL00675 K02340; COG: COG1466 DNA polymerase III, delta subunit; Psort location: Cytoplasmic, score: 8.87.
  
 0.991
dnaX
DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
 
 0.991
EDS73970.1
KEGG: btl:BALH_0027 5.9e-40 holB; DNA polymerase III, delta prime subunit K00961; COG: COG0470 ATPase involved in DNA replication; Psort location: CytoplasmicMembrane, score: 7.80.
 
 0.990
EDS76050.1
SWIM zinc finger domain protein; KEGG: cpr:CPR_1663 6.0e-08 polC; DNA polymerase III, alpha subunit, gram-positive type K03763; COG: COG0847 DNA polymerase III, epsilon subunit and related 3-5 exonucleases; Psort location: Cytoplasmic, score: 8.87.
   
 0.960
EDS74024.1
KEGG: shn:Shewana3_3590 2.8e-17 single-strand binding protein K00655; COG: COG0629 Single-stranded DNA-binding protein.
 
 
 0.938
EDS74908.1
KEGG: shn:Shewana3_3590 0.00013 single-strand binding protein K00655; COG: COG0629 Single-stranded DNA-binding protein; Psort location: Cytoplasmic, score: 8.87.
   
 0.923
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 
 0.904
polC
DNA polymerase III, alpha subunit, Gram-positive type; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
    
0.888
mutM
DNA-formamidopyrimidine glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
     
 0.830
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.