STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDS75817.1Class II glutamine amidotransferase; KEGG: syn:sll1502 0. gltB; NADH-dependent glutamate synthase large subunit K00268; COG: COG0069 Glutamate synthase domain 2; Psort location: Cytoplasmic, score: 8.87. (1511 aa)    
Predicted Functional Partners:
EDS75818.1
Pyridine nucleotide-disulfide oxidoreductase; KEGG: syn:sll1027 1.8e-132 gltD; NADH-dependent glutamate synthase small subunit K00269; COG: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases; Psort location: Cytoplasmic, score: 9.98.
 0.999
gltA
KEGG: chy:CHY_1991 3.5e-161 gltA; glutamate synthase (NADPH), homotetrameric K00266; COG: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases; Psort location: Cytoplasmic, score: 9.98.
 
 0.999
EDS75221.1
Glu/Leu/Phe/Val dehydrogenase, dimerization domain protein; KEGG: fth:FTH_0268 4.7e-157 glutamate dehydrogenase (NADP(+)) K00262; COG: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Psort location: Cytoplasmic, score: 9.98; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 0.997
glnA
Glutamate--ammonia ligase, catalytic domain protein; KEGG: tte:TTE0821 2.5e-229 glnA; Glutamine synthase K01915; COG: COG3968 Uncharacterized protein related to glutamine synthetase; Psort location: Cytoplasmic, score: 9.65.
  
 
 0.982
asnB-2
Asparagine synthase (glutamine-hydrolyzing); KEGG: lla:L00396 6.2e-155 asnB; asparagine synthetase B K01953; COG: COG0367 Asparagine synthase (glutamine-hydrolyzing); Psort location: Cytoplasmic, score: 8.87.
  
 
 0.974
EDS74665.1
Glutamine synthetase, beta-grasp domain protein; KEGG: mma:MM0964 3.0e-91 glutamine synthetase K01915; COG: COG0174 Glutamine synthetase; Psort location: Cytoplasmic, score: 9.98.
  
 
 0.974
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.970
guaA
GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP.
  
 
 0.961
nifJ
KEGG: fnu:FN1170 0. pyruvate-flavodoxin oxidoreductase K03737; COG: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.960
EDS75141.1
KEGG: efa:EF1922 0.00014 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: Cytoplasmic, score: 9.98.
    
 
 0.957
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.