STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDS75982.1Hypothetical protein; KEGG: bce:BC2348 0.00018 acetyltransferase K00680; COG: COG1357 Uncharacterized low-complexity proteins; Psort location: Cytoplasmic, score: 8.87. (211 aa)    
Predicted Functional Partners:
parE
DNA topoisomerase IV, B subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 2 subfamily.
   
 
 0.663
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.663
typA
GTP-binding protein TypA; KEGG: eci:UTI89_C4460 4.4e-177 typA, bipA, yihK, yjhK; putative GTP-binding factor K06207; COG: COG1217 Predicted membrane GTPase involved in stress response; Psort location: Cytoplasmic, score: 9.98.
       0.645
EDS75980.1
KEGG: lwe:lwe2133 1.8e-68 ABC transporter, ATP-binding protein K06020; COG: COG1136 ABC-type antimicrobial peptide transport system, ATPase component; Psort location: CytoplasmicMembrane, score: 9.49.
     
 0.618
EDS75981.1
Efflux ABC transporter, permease protein; KEGG: pto:PTO0924 0.0020 signal peptidase I K03100; COG: COG0577 ABC-type antimicrobial peptide transport system, permease component; Psort location: CytoplasmicMembrane, score: 9.99.
     
 0.618
EDS74488.1
SH3 domain protein; KEGG: lwe:lwe1534 0.00025 N-acetylmuramoyl-L-alanine amidase K01446; COG: COG3757 Lyzozyme M1 (1,4-beta-N-acetylmuramidase); Psort location: Cytoplasmic, score: 8.87.
   
 
 0.577
EDS74251.1
Hypothetical protein; COG: COG3595 Uncharacterized conserved protein.
   
   0.570
EDS75230.1
LysM domain protein; KEGG: aeh:Mlg_1995 5.1e-06 lytic transglycosylase, catalytic K08307; COG: COG3409 Putative peptidoglycan-binding domain-containing protein.
   
 
 0.557
EDS75979.1
ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; KEGG: cpf:CPF_0116 7.6e-79 sensor histidine kinase; COG: COG0642 Signal transduction histidine kinase; Psort location: CytoplasmicMembrane, score: 10.00.
 
   
 0.529
EDS75984.1
Hypothetical protein; Psort location: Cytoplasmic, score: 8.87.
       0.474
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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