STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDS75482.1Putative endoribonuclease L-PSP; KEGG: ape:APE_1501.1 1.6e-23 ribonuclease UK114; COG: COG0251 Putative translation initiation inhibitor, yjgF family. (124 aa)    
Predicted Functional Partners:
EDS74218.1
Chorismate mutase; KEGG: aae:aq_951 3.3e-53 pheA; chorismate mutase/prephenate dehydratase K04093:K04518; COG: COG0077 Prephenate dehydratase; Psort location: Cytoplasmic, score: 9.98.
  
 
 0.872
EDS75783.1
KEGG: tte:TTE2333 3.0e-155 fusA2; translation elongation and release factors (GTPases) K02355; COG: COG0480 Translation elongation factors (GTPases); Psort location: Cytoplasmic, score: 9.98.
   
 0.775
EDS75044.1
KEGG: pmn:PMN2A_1075 7.9e-68 translation elongation factor G:small GTP-binding protein domain K02355; COG: COG0480 Translation elongation factors (GTPases); Psort location: Cytoplasmic, score: 9.98.
   
 0.775
fusA
Translation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...]
   
 0.775
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.765
EDS74629.1
Alcohol dehydrogenase, iron-dependent; KEGG: msu:MS2190 0. eutG; alcohol dehydrogenase IV K00001:K04072; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: Cytoplasmic, score: 9.98; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
  
 0.696
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
    
 0.692
EDS74222.1
Glycerate kinase; KEGG: sak:SAK_0918 1.7e-106 glycerate kinase K00865; COG: COG1929 Glycerate kinase; Psort location: Cytoplasmic, score: 8.87; Belongs to the glycerate kinase type-1 family.
 
    0.682
ilvE
Branched-chain-amino-acid transaminase; KEGG: bha:BH2156 1.6e-110 bcaT; branched-chain amino acid aminotransferase K00826; COG: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.671
guaA
GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP.
  
 
 0.663
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.