| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EDS75487.1 | EDS75489.1 | CLOSPI_00524 | CLOSPI_00526 | Adenylate cyclase; KEGG: sar:SAR0971 6.8e-23 glutathione S-transferase K00799; COG: COG4116 Uncharacterized protein conserved in bacteria; Psort location: Cytoplasmic, score: 8.87. | Pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | 0.618 |
| EDS75487.1 | nadK | CLOSPI_00524 | CLOSPI_00525 | Adenylate cyclase; KEGG: sar:SAR0971 6.8e-23 glutathione S-transferase K00799; COG: COG4116 Uncharacterized protein conserved in bacteria; Psort location: Cytoplasmic, score: 8.87. | NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.618 |
| EDS75489.1 | EDS75487.1 | CLOSPI_00526 | CLOSPI_00524 | Pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | Adenylate cyclase; KEGG: sar:SAR0971 6.8e-23 glutathione S-transferase K00799; COG: COG4116 Uncharacterized protein conserved in bacteria; Psort location: Cytoplasmic, score: 8.87. | 0.618 |
| EDS75489.1 | nadK | CLOSPI_00526 | CLOSPI_00525 | Pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.811 |
| EDS75489.1 | yqeH | CLOSPI_00526 | CLOSPI_01238 | Pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | Ribosome biogenesis GTPase YqeH; KEGG: lil:LA0134 0.00025 hypothetical protein K06949; COG: COG1161 Predicted GTPases; Psort location: Cytoplasmic, score: 8.87. | 0.473 |
| EDS75995.1 | nadD | CLOSPI_00108 | CLOSPI_01240 | Transcriptional regulator, Sir2 family; KEGG: tte:TTE1570 7.9e-13 sir2; NAD-dependent protein deacetylase, Sir2 family K01463; COG: COG0846 NAD-dependent protein deacetylases, SIR2 family; Psort location: Cytoplasmic, score: 8.87. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.928 |
| EDS75995.1 | nadE | CLOSPI_00108 | CLOSPI_00417 | Transcriptional regulator, Sir2 family; KEGG: tte:TTE1570 7.9e-13 sir2; NAD-dependent protein deacetylase, Sir2 family K01463; COG: COG0846 NAD-dependent protein deacetylases, SIR2 family; Psort location: Cytoplasmic, score: 8.87. | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.951 |
| EDS75995.1 | nadK | CLOSPI_00108 | CLOSPI_00525 | Transcriptional regulator, Sir2 family; KEGG: tte:TTE1570 7.9e-13 sir2; NAD-dependent protein deacetylase, Sir2 family K01463; COG: COG0846 NAD-dependent protein deacetylases, SIR2 family; Psort location: Cytoplasmic, score: 8.87. | NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.909 |
| ffh | miaA | CLOSPI_00942 | CLOSPI_01407 | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.415 |
| ffh | nadD | CLOSPI_00942 | CLOSPI_01240 | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.439 |
| ffh | nadK | CLOSPI_00942 | CLOSPI_00525 | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.486 |
| ffh | sun | CLOSPI_00942 | CLOSPI_00554 | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.429 |
| miaA | ffh | CLOSPI_01407 | CLOSPI_00942 | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.415 |
| miaA | nadK | CLOSPI_01407 | CLOSPI_00525 | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.502 |
| miaA | sun | CLOSPI_01407 | CLOSPI_00554 | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.422 |
| nadD | EDS75995.1 | CLOSPI_01240 | CLOSPI_00108 | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Transcriptional regulator, Sir2 family; KEGG: tte:TTE1570 7.9e-13 sir2; NAD-dependent protein deacetylase, Sir2 family K01463; COG: COG0846 NAD-dependent protein deacetylases, SIR2 family; Psort location: Cytoplasmic, score: 8.87. | 0.928 |
| nadD | ffh | CLOSPI_01240 | CLOSPI_00942 | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.439 |
| nadD | nadE | CLOSPI_01240 | CLOSPI_00417 | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.964 |
| nadD | nadK | CLOSPI_01240 | CLOSPI_00525 | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.946 |
| nadD | yqeH | CLOSPI_01240 | CLOSPI_01238 | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Ribosome biogenesis GTPase YqeH; KEGG: lil:LA0134 0.00025 hypothetical protein K06949; COG: COG1161 Predicted GTPases; Psort location: Cytoplasmic, score: 8.87. | 0.918 |
