STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDS75546.1Nuclease-like protein; KEGG: efa:EF0511 2.0e-23 nuc-1; thermonuclease precursor K01174; COG: COG1525 Micrococcal nuclease (thermonuclease) homologs; Psort location: Extracellular, score: 10.00. (177 aa)    
Predicted Functional Partners:
EDS75113.1
Molybdopterin binding domain protein; KEGG: mmu:319945 0.00014 Flad1; RFad1, flavin adenine dinucleotide synthetase, homolog (yeast) K00953; COG: COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; Psort location: Cytoplasmic, score: 8.87.
    
  0.878
EDS74810.1
Competence/damage-inducible domain protein CinA; COG: COG1546 Uncharacterized protein (competence- and mitomycin-induced); Psort location: Cytoplasmic, score: 8.87; Belongs to the CinA family.
    
  0.878
guaA
GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP.
    
  0.866
rnhA
Ribonuclease HI; KEGG: cpr:CPR_1436 1.0e-35 RNAse H family protein K01163; COG: COG3341 Predicted double-stranded RNA/RNA-DNA hybrid binding protein; Psort location: Cytoplasmic, score: 8.87.
       0.773
EDS74818.1
KEGG: lmf:LMOf2365_0150 3.1e-215 inosine-5'-monophosphate dehydrogenase, putative K00088; COG: COG0516 IMP dehydrogenase/GMP reductase; Psort location: Cytoplasmic, score: 8.87.
    
 0.643
nadD
Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
    
  0.617
purA
Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
    
 0.616
purH
KEGG: cpf:CPF_0677 2.0e-133 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase K00602:K01492; COG: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); Psort location: Cytoplasmic, score: 8.87.
  
 
  0.612
nadC
Nicotinate-nucleotide diphosphorylase (carboxylating); KEGG: cpe:CPE0396 1.0e-81 nadC; nicotinate-nucleotide pyrophosphorylase K00767; COG: COG0157 Nicotinate-nucleotide pyrophosphorylase; Psort location: Cytoplasmic, score: 9.65; Belongs to the NadC/ModD family.
    
  0.604
rdgB
Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
    
  0.603
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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