STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDS75342.1Riboflavin biosynthesis protein RibD C-terminal domain protein; KEGG: chu:CHU_1297 8.1e-27 dfr; dihydrofolate reductase family protein K00287; COG: COG0262 Dihydrofolate reductase; Psort location: Cytoplasmic, score: 8.87. (176 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.873
EDS75105.1
KEGG: ctc:CTC01806 2.7e-209 5-methyltetrahydrofolate--homocysteine methyltransferase K00548; COG: COG1410 Methionine synthase I, cobalamin-binding domain; Psort location: Cytoplasmic, score: 8.87.
    
 0.851
sigF
KEGG: hpa:HPAG1_0089 4.4e-23 RNA polymerase sigma-80 factor K00960; COG: COG1191 DNA-directed RNA polymerase specialized sigma subunit; Psort location: Cytoplasmic, score: 9.98; Belongs to the sigma-70 factor family.
   
    0.568
EDS76003.1
Trypsin; KEGG: bsu:BG11054 1.1e-70 yyxA, yycK; similar to serine protease Do; COG: COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain.
  
    0.566
rpoD
RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
  
  
 0.522
tdk
Thymidine kinase; KEGG: bha:BH3779 1.8e-63 tdk; thymidine kinase K00857; COG: COG1435 Thymidine kinase; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.497
EDS75164.1
Alcohol dehydrogenase, iron-dependent; KEGG: ctc:CTC00408 1.1e-104 NADH-dependent butanol dehydrogenase A K00100; COG: COG1979 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family; Psort location: Cytoplasmic, score: 9.98.
  
    0.488
EDS73742.1
KEGG: cno:NT01CX_1542 4.6e-79 alcohol dehydrogenase, iron-containing K00100; COG: COG1979 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family; Psort location: Cytoplasmic, score: 9.65.
  
    0.488
EDS75098.1
Cytidine and deoxycytidylate deaminase zinc-binding region; KEGG: fnu:FN1902 5.3e-55 deoxycytidylate deaminase K01493; COG: COG2131 Deoxycytidylate deaminase; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.487
EDS75723.1
Aldehyde dehydrogenase (NAD) family protein; KEGG: ctc:CTC02523 8.9e-108 ywdH; putative aldehyde dehydrogenase YwdH K00128; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: Cytoplasmic, score: 9.98.
  
 
 0.454
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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