Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mltGYceG family protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (367 aa)    
Predicted Functional Partners:
EDS75364.1
O-methyltransferase; KEGG: bce:BC4378 2.7e-35 caffeoyl-CoA O-methyltransferase K00588; COG: COG4122 Predicted O-methyltransferase; Psort location: Cytoplasmic, score: 8.87.
  
    0.814
EDS75362.1
Peptidase, U32 family; KEGG: gka:GK2549 3.8e-116 protease K08303; COG: COG0826 Collagenase and related proteases; Psort location: Cytoplasmic, score: 8.87.
  
    0.787
EDS75363.1
Peptidase, U32 family; KEGG: baa:BA_5051 1.0e-28 peptidase family U32 K08303; COG: COG0826 Collagenase and related proteases; Psort location: Cytoplasmic, score: 8.87.
  
    0.787
ftsA
Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family.
 
  
 0.713
EDS76019.1
Penicillin-binding protein, transpeptidase domain protein; KEGG: swo:Swol_0820 7.7e-54 peptidoglycan glycosyltransferase K05364; COG: COG0768 Cell division protein FtsI/penicillin-binding protein 2; Psort location: CytoplasmicMembrane, score: 9.82.
 
  
 0.696
ponA
KEGG: gka:GK2168 7.4e-104 penicillin-binding protein 1A/1B (PBP1) (penicillin-insensitive transglycosylase (peptidoglycan TGase); penicillin-sensitive transpeptidase (DD-transpeptidase)) K05366; COG: COG0744 Membrane carboxypeptidase (penicillin-binding protein); Psort location: Extracellular, score: 9.73.
 
   
 0.693
greA
Prokaryotic transcription elongation factor, GreA/GreB domain protein; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
     
 0.660
ftsZ
Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
 
  
 0.581
EDS75892.1
Putative shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
  
    0.572
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.572
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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