STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDS75273.1KEGG: baa:BA_4936 1.1e-29 5-formyltetrahydrofolate cyclo-ligase family K01934; COG: COG0212 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (177 aa)    
Predicted Functional Partners:
folD
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
 
  
 0.958
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
  
 
 0.906
EDS75275.1
SUF system FeS assembly protein, NifU family; COG: COG0822 NifU homolog involved in Fe-S cluster formation; Psort location: Cytoplasmic, score: 8.87.
   
   0.829
sufB
FeS assembly protein SufB; COG: COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component; Psort location: Cytoplasmic, score: 8.87.
       0.820
sufS
Cysteine desulfurase, SufS subfamily; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.
       0.815
EDS75277.1
SufB/sufD domain protein; KEGG: pfa:MAL13P1.278 0.0032 Ser/Thr protein kinase K00870; COG: COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component; Psort location: Cytoplasmic, score: 8.87.
       0.815
sufC
KEGG: ava:Ava_0425 9.7e-63 sufC; FeS assembly ATPase SufC K09013; COG: COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Psort location: CytoplasmicMembrane, score: 9.49.
       0.815
EDS75279.1
Hypothetical protein; Psort location: Extracellular, score: 8.82.
       0.768
fmt
methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
  
 
 0.758
fhs
KEGG: mta:Moth_0109 5.8e-207 formate--tetrahydrofolate ligase K01938; COG: COG2759 Formyltetrahydrofolate synthetase; Psort location: Cytoplasmic, score: 8.87.
   
 0.706
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.