Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
recXRegulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. (668 aa)    
Predicted Functional Partners:
EDS75287.1
Glycosyltransferase, group 1 family protein; KEGG: lsa:LSA1206 1.3e-88 putative glycosyl transferase, group 1 K00754; COG: COG0438 Glycosyltransferase; Psort location: Cytoplasmic, score: 8.87.
 
  
 
0.986
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.962
mprF
Hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.
 
  
 0.912
EDS75543.1
Lipid kinase, YegS/Rv2252/BmrU family; KEGG: eci:UTI89_C2362 2.6e-17 hypothetical protein; COG: COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase.
  
 
  0.903
EDS75268.1
KEGG: oih:OB1952 2.4e-20 dgkA; diacylglycerol kinase K00901; COG: COG0818 Diacylglycerol kinase.
    
  0.900
EDS75284.1
Nucleic acid-binding domain protein; COG: COG3481 Predicted HD-superfamily hydrolase; Psort location: Cytoplasmic, score: 8.87.
  
    0.826
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 
 0.705
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
   
 
 0.688
glgB
1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position. Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
  
 0.656
EDS75475.1
DNA internalization competence protein ComEC/Rec2-like protein; KEGG: cel:ND6 0.00029 NADH dehydrogenase subunit 6 K03884; COG: COG0658 Predicted membrane metal-binding protein; Psort location: CytoplasmicMembrane, score: 9.99.
 
  
 0.622
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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