Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
EDS74846.1Oxidoreductase; COG: NOG16874 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87. (139 aa)    
Predicted Functional Partners:
proB
Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
     
 0.717
proA
Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
  
    0.692
clpP
Endopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
    
 
 0.665
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
  
 0.629
EDS74843.1
Hypothetical protein; KEGG: ctc:CTC01982 0.0016 L-serine dehydratase alpha subunit K01752; COG: COG3681 Uncharacterized conserved protein; Psort location: Cytoplasmic, score: 9.98; Belongs to the UPF0597 family.
       0.623
birA
biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
  
 0.546
EDS74218.1
Chorismate mutase; KEGG: aae:aq_951 3.3e-53 pheA; chorismate mutase/prephenate dehydratase K04093:K04518; COG: COG0077 Prephenate dehydratase; Psort location: Cytoplasmic, score: 9.98.
     
 0.504
EDS75346.1
Pyridine nucleotide-disulfide oxidoreductase; KEGG: bce:BC0791 4.5e-136 NADH dehydrogenase K00359; COG: COG0607 Rhodanese-related sulfurtransferase; Psort location: Cytoplasmic, score: 9.65; Belongs to the sulfur carrier protein TusA family.
 
  
 0.447
asnA
Aspartate--ammonia ligase; KEGG: lsl:LSL_1033 8.2e-137 asnA; aspartate--ammonia ligase K01914; COG: COG2502 Asparagine synthetase A; Psort location: Cytoplasmic, score: 10.00.
       0.434
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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