Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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Score
parEDNA topoisomerase IV, B subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 2 subfamily. (642 aa)    
Predicted Functional Partners:
parC
DNA topoisomerase IV, A subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.
 
 0.997
gyrA
DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
 0.993
truB
tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
  
 
 0.746
EDS75727.1
SNF2 family N-terminal domain protein; KEGG: lwe:lwe1660 2.5e-119 DNA/RNA helicase protein K01529; COG: COG0553 Superfamily II DNA/RNA helicases, SNF2 family; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.729
plsY
Acyl-phosphate glycerol 3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
     
 0.647
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
  
 0.628
EDS75506.1
Efflux ABC transporter, permease protein; KEGG: cal:orf19.2410 6.5e-06 IMH1; involved in vesicular transport K01553; COG: COG0577 ABC-type antimicrobial peptide transport system, permease component; Psort location: CytoplasmicMembrane, score: 10.00.
   
 
 0.586
smc
Chromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family.
   
 
 0.586
EDS74737.1
TIGR02680 family protein; KEGG: cal:orf19.6294 3.7e-20 MYO1; class II myosin heavy chain K01553; COG: NOG04768 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87.
   
 
 0.586
EDS75957.1
KEGG: tma:TM1430 1.5e-21 glycerol kinase K00864; COG: COG0554 Glycerol kinase; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.552
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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