STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDS74933.1ACT domain protein; KEGG: nph:NP5006A 6.0e-08 purU; formyltetrahydrofolate deformylase K01433; COG: COG3830 ACT domain-containing protein; Psort location: Cytoplasmic, score: 8.87; Belongs to the UPF0237 family. (99 aa)    
Predicted Functional Partners:
EDS74934.1
Hypothetical protein; KEGG: bja:blr0807 0.0058 succinate-semialdehyde dehydrogenase K00135; COG: COG2848 Uncharacterized conserved protein; Psort location: Cytoplasmic, score: 8.87.
 
     0.951
ilvA
Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
    
  0.852
serC
Phosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.
     
 0.671
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.654
EDS75473.1
KEGG: bth:BT4678 3.0e-100 L-serine dehydratase K01752; COG: COG1760 L-serine deaminase; Psort location: Cytoplasmic, score: 8.87.
     
 0.648
EDS75777.1
Putative HAD hydrolase, family IB; KEGG: ctc:CTC01739 1.4e-29 phosphoserine phosphatase K01079; COG: COG0560 Phosphoserine phosphatase; Psort location: Cytoplasmic, score: 8.87.
    
 0.621
cysE
KEGG: gka:GK0084 1.5e-50 serine O-acetyltransferase K00640; COG: COG1045 Serine acetyltransferase; Psort location: Cytoplasmic, score: 9.98.
     
 0.621
EDS74936.1
Hypothetical protein; KEGG: fnu:FN1041 2.0e-14 acetyltransferase K00680; COG: COG4866 Uncharacterized conserved protein; Psort location: Cytoplasmic, score: 8.87.
       0.616
EDS74935.1
Hypothetical protein; COG: COG2607 Predicted ATPase (AAA+ superfamily).
       0.615
EDS75697.1
KEGG: aae:aq_1812 4.4e-67 thrA; homoserine dehydrogenase K00003; COG: COG0460 Homoserine dehydrogenase; Psort location: Cytoplasmic, score: 8.87.
    
  0.603
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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