STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
coaXPantothenate kinase, type III; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (257 aa)    
Predicted Functional Partners:
coaBC
Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.
 
 
 0.979
coaD
Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
 
  
 0.928
EDS75018.1
COG: COG4684 Predicted membrane protein; Psort location: CytoplasmicMembrane, score: 9.99.
       0.820
birA
biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
    0.795
cmk
Cytidylate kinase; KEGG: bca:BCE_1623 2.5e-55 cmk; cytidylate kinase K00945; COG: COG0283 Cytidylate kinase; Psort location: Cytoplasmic, score: 8.87.
 
  
 0.674
tmk
dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
   
   0.665
EDS74073.1
Putative CoA-substrate-specific enzyme activase; KEGG: rpc:RPC_1027 2.7e-19 benzoyl-CoA reductase, subunit A K04114; COG: COG3580 Uncharacterized protein conserved in bacteria; Psort location: Cytoplasmic, score: 8.87.
     
 0.574
EDS75017.1
DJ-1 family protein; KEGG: lic:LIC11685 6.3e-20 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis K03152; COG: COG0693 Putative intracellular protease/amidase; Psort location: Cytoplasmic, score: 8.87.
       0.524
hslO
Chaperonin HslO; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
  
    0.452
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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