STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
ahpCPeroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (187 aa)    
Predicted Functional Partners:
EDS75992.1
Hypothetical protein; KEGG: fnu:FN1984 0.00068 thioredoxin reductase / glutaredoxin-like protein K00384; COG: COG0526 Thiol-disulfide isomerase and thioredoxins; Psort location: Cytoplasmic, score: 8.87.
  
 0.999
EDS74806.1
Putative thioredoxin-disulfide reductase; KEGG: cpe:CPE0783 1.3e-122 probable thioredoxin reductase K00384; COG: COG0526 Thiol-disulfide isomerase and thioredoxins; Psort location: Cytoplasmic, score: 9.65.
 
 
 0.999
trxB
KEGG: bcl:ABC3038 3.0e-84 trxB; thioredoxin reductase K00384; COG: COG0492 Thioredoxin reductase; Psort location: Cytoplasmic, score: 9.65.
  
 
 0.847
EDS74965.1
Rubredoxin; KEGG: syn:sll0550 3.3e-46 flavoprotein; COG: COG0426 Uncharacterized flavoproteins; Psort location: Cytoplasmic, score: 8.87.
  
  
 0.714
EDS75907.1
Transcriptional regulator, Fur family; COG: COG0735 Fe2+/Zn2+ uptake regulation proteins; Psort location: Cytoplasmic, score: 8.87; Belongs to the Fur family.
  
  
 0.691
nifJ
KEGG: fnu:FN1170 0. pyruvate-flavodoxin oxidoreductase K03737; COG: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit; Psort location: Cytoplasmic, score: 8.87.
  
  
 0.646
EDS75017.1
DJ-1 family protein; KEGG: lic:LIC11685 6.3e-20 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis K03152; COG: COG0693 Putative intracellular protease/amidase; Psort location: Cytoplasmic, score: 8.87.
   
 
 0.640
grpE
Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]
   
 
 0.620
trxA
Thioredoxin; KEGG: hpa:HPAG1_0810 1.7e-17 thioredoxin K05905; COG: COG0526 Thiol-disulfide isomerase and thioredoxins; Psort location: Cytoplasmic, score: 9.65; Belongs to the thioredoxin family.
  
 
 0.591
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
   
 
 0.590
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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