| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EDS74144.1 | dnaN | CLOSPI_01726 | CLOSPI_02412 | UvrD/REP helicase; KEGG: mmo:MMOB4890 1.4e-141 pcrA1; ATP-dependent DNA helicase K03657; COG: COG0210 Superfamily I DNA and RNA helicases; Psort location: Cytoplasmic, score: 8.87. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.931 |
| EDS74144.1 | mutL | CLOSPI_01726 | CLOSPI_01406 | UvrD/REP helicase; KEGG: mmo:MMOB4890 1.4e-141 pcrA1; ATP-dependent DNA helicase K03657; COG: COG0210 Superfamily I DNA and RNA helicases; Psort location: Cytoplasmic, score: 8.87. | DNA mismatch repair domain protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.869 |
| EDS74144.1 | polA | CLOSPI_01726 | CLOSPI_00138 | UvrD/REP helicase; KEGG: mmo:MMOB4890 1.4e-141 pcrA1; ATP-dependent DNA helicase K03657; COG: COG0210 Superfamily I DNA and RNA helicases; Psort location: Cytoplasmic, score: 8.87. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.901 |
| EDS74144.1 | recA | CLOSPI_01726 | CLOSPI_01396 | UvrD/REP helicase; KEGG: mmo:MMOB4890 1.4e-141 pcrA1; ATP-dependent DNA helicase K03657; COG: COG0210 Superfamily I DNA and RNA helicases; Psort location: Cytoplasmic, score: 8.87. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.897 |
| EDS74144.1 | sbcD | CLOSPI_01726 | CLOSPI_00042 | UvrD/REP helicase; KEGG: mmo:MMOB4890 1.4e-141 pcrA1; ATP-dependent DNA helicase K03657; COG: COG0210 Superfamily I DNA and RNA helicases; Psort location: Cytoplasmic, score: 8.87. | Exonuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.721 |
| EDS75944.1 | dnaN | CLOSPI_00474 | CLOSPI_02412 | MutS domain V protein; KEGG: bcz:BCZK3528 1.4e-12 mutS; DNA mismatch repair protein, MutS family K03555; COG: COG0249 Mismatch repair ATPase (MutS family); Psort location: CytoplasmicMembrane, score: 9.99. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.901 |
| EDS75944.1 | mutL | CLOSPI_00474 | CLOSPI_01406 | MutS domain V protein; KEGG: bcz:BCZK3528 1.4e-12 mutS; DNA mismatch repair protein, MutS family K03555; COG: COG0249 Mismatch repair ATPase (MutS family); Psort location: CytoplasmicMembrane, score: 9.99. | DNA mismatch repair domain protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.975 |
| EDS75944.1 | polA | CLOSPI_00474 | CLOSPI_00138 | MutS domain V protein; KEGG: bcz:BCZK3528 1.4e-12 mutS; DNA mismatch repair protein, MutS family K03555; COG: COG0249 Mismatch repair ATPase (MutS family); Psort location: CytoplasmicMembrane, score: 9.99. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.912 |
| EDS75944.1 | recA | CLOSPI_00474 | CLOSPI_01396 | MutS domain V protein; KEGG: bcz:BCZK3528 1.4e-12 mutS; DNA mismatch repair protein, MutS family K03555; COG: COG0249 Mismatch repair ATPase (MutS family); Psort location: CytoplasmicMembrane, score: 9.99. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.673 |
| EDS75944.1 | sbcD | CLOSPI_00474 | CLOSPI_00042 | MutS domain V protein; KEGG: bcz:BCZK3528 1.4e-12 mutS; DNA mismatch repair protein, MutS family K03555; COG: COG0249 Mismatch repair ATPase (MutS family); Psort location: CytoplasmicMembrane, score: 9.99. | Exonuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.430 |
| dnaN | EDS74144.1 | CLOSPI_02412 | CLOSPI_01726 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | UvrD/REP helicase; KEGG: mmo:MMOB4890 1.4e-141 pcrA1; ATP-dependent DNA helicase K03657; COG: COG0210 Superfamily I DNA and RNA helicases; Psort location: Cytoplasmic, score: 8.87. | 0.931 |
| dnaN | EDS75944.1 | CLOSPI_02412 | CLOSPI_00474 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | MutS domain V protein; KEGG: bcz:BCZK3528 1.4e-12 mutS; DNA mismatch repair protein, MutS family K03555; COG: COG0249 Mismatch repair ATPase (MutS family); Psort location: CytoplasmicMembrane, score: 9.99. | 0.901 |
| dnaN | mutL | CLOSPI_02412 | CLOSPI_01406 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA mismatch repair domain protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.973 |
| dnaN | mutS | CLOSPI_02412 | CLOSPI_01405 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.915 |
| dnaN | polA | CLOSPI_02412 | CLOSPI_00138 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.995 |
| dnaN | recA | CLOSPI_02412 | CLOSPI_01396 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.915 |
| mfd | mutL | CLOSPI_00074 | CLOSPI_01406 | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | DNA mismatch repair domain protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.694 |
| mfd | mutS | CLOSPI_00074 | CLOSPI_01405 | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.469 |
| mfd | polA | CLOSPI_00074 | CLOSPI_00138 | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.698 |
| miaA | mutL | CLOSPI_01407 | CLOSPI_01406 | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | DNA mismatch repair domain protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.953 |
