STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cas2-2CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (105 aa)    
Predicted Functional Partners:
cas1-2
CRISPR-associated endonuclease Cas1, HMARI/TNEAP subtype; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
 
 0.996
cas4
CRISPR-associated protein Cas4; COG: COG1468 RecB family exonuclease; Psort location: Cytoplasmic, score: 8.87.
 
 
 
 0.994
cas3
CRISPR-associated helicase Cas3; KEGG: afu:AF0071 9.0e-16 ATP-dependent RNA helicase, putative; COG: COG1203 Predicted helicases; Psort location: Cytoplasmic, score: 8.87.
 
  
 0.957
cas1
CRISPR-associated endonuclease Cas1, NMENI subtype; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
  
 
 0.910
EDS74678.1
Hypothetical protein.
       0.773
EDS74683.1
Integrase core domain protein; KEGG: nwi:Nwi_0782 3.2e-10 integrase, catalytic region K00986; COG: COG2801 Transposase and inactivated derivatives; Psort location: Cytoplasmic, score: 8.87.
       0.600
EDS74684.1
Transposase; COG: COG2963 Transposase and inactivated derivatives; Psort location: Cytoplasmic, score: 8.87.
       0.457
hup
DNA-binding protein HU; KEGG: pub:SAR11_0607 0.00046 sfhB; pseudouridylate synthase K06180; COG: COG0776 Bacterial nucleoid DNA-binding protein; Psort location: Cytoplasmic, score: 8.87; Belongs to the bacterial histone-like protein family.
    
   0.430
hup-2
DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
    
   0.430
EDS76132.1
Group II intron, maturase-specific domain protein; KEGG: pol:Bpro_5394 8.3e-26 RNA-directed DNA polymerase K00986; COG: COG3344 Retron-type reverse transcriptase; Psort location: Cytoplasmic, score: 8.87.
   
   0.427
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.