STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cas3CRISPR-associated helicase Cas3; KEGG: afu:AF0071 9.0e-16 ATP-dependent RNA helicase, putative; COG: COG1203 Predicted helicases; Psort location: Cytoplasmic, score: 8.87. (720 aa)    
Predicted Functional Partners:
cas4
CRISPR-associated protein Cas4; COG: COG1468 RecB family exonuclease; Psort location: Cytoplasmic, score: 8.87.
 
  
 0.958
cas2-2
CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
  
 0.957
cas1-2
CRISPR-associated endonuclease Cas1, HMARI/TNEAP subtype; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
  
 0.955
EDS74678.1
Hypothetical protein.
       0.757
EDS74683.1
Integrase core domain protein; KEGG: nwi:Nwi_0782 3.2e-10 integrase, catalytic region K00986; COG: COG2801 Transposase and inactivated derivatives; Psort location: Cytoplasmic, score: 8.87.
       0.613
EDS74684.1
Transposase; COG: COG2963 Transposase and inactivated derivatives; Psort location: Cytoplasmic, score: 8.87.
       0.466
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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