Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
EDS74568.1DnaJ domain protein; COG: COG2214 DnaJ-class molecular chaperone; Psort location: Cytoplasmic, score: 9.65. (202 aa)    
Predicted Functional Partners:
dnaK-2
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 0.994
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 0.978
grpE
Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]
 
 
 0.969
EDS74567.1
Hypothetical protein; COG: NOG23778 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87.
 
     0.948
htpG
Chaperone protein HtpG; Molecular chaperone. Has ATPase activity.
  
 0.944
nifJ
KEGG: fnu:FN1170 0. pyruvate-flavodoxin oxidoreductase K03737; COG: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit; Psort location: Cytoplasmic, score: 8.87.
  
 0.930
groL
Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 0.871
EDS75763.1
Hypothetical protein; KEGG: pub:SAR11_0453 8.8e-05 aroK; shikimate kinase K00891.
 
 
 0.866
EDS74566.1
Hypothetical protein; COG: NOG18757 non supervised orthologous group.
 
     0.853
EDS74574.1
FAD dependent oxidoreductase; KEGG: mma:MM1656 1.6e-55 oxidoreductase K00100; COG: COG0665 Glycine/D-amino acid oxidases (deaminating); Psort location: Cytoplasmic, score: 8.87.
   
 0.847
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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