| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EDS74167.1 | EDS74616.1 | CLOSPI_01749 | CLOSPI_01671 | Pseudouridine synthase, RluA family; KEGG: baa:BA_1831 2.2e-49 PseudoU_synth_2, RNA pseudouridylate synthase K06180; COG: COG0564 Pseudouridylate synthases, 23S RNA-specific. | RNA methyltransferase, TrmH family, group 3; KEGG: lin:lin0273 1.4e-61 putative tRNA/rRNA methyltransferase K03218; COG: COG0566 rRNA methylases; Psort location: Cytoplasmic, score: 8.87; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | 0.606 |
| EDS74167.1 | cgtA | CLOSPI_01749 | CLOSPI_00881 | Pseudouridine synthase, RluA family; KEGG: baa:BA_1831 2.2e-49 PseudoU_synth_2, RNA pseudouridylate synthase K06180; COG: COG0564 Pseudouridylate synthases, 23S RNA-specific. | Obg family GTPase CgtA; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 0.772 |
| EDS74167.1 | hflB | CLOSPI_01749 | CLOSPI_02241 | Pseudouridine synthase, RluA family; KEGG: baa:BA_1831 2.2e-49 PseudoU_synth_2, RNA pseudouridylate synthase K06180; COG: COG0564 Pseudouridylate synthases, 23S RNA-specific. | ATP-dependent metallopeptidase HflB; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.593 |
| EDS74167.1 | rplC | CLOSPI_01749 | CLOSPI_01569 | Pseudouridine synthase, RluA family; KEGG: baa:BA_1831 2.2e-49 PseudoU_synth_2, RNA pseudouridylate synthase K06180; COG: COG0564 Pseudouridylate synthases, 23S RNA-specific. | 50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | 0.584 |
| EDS74167.1 | rplM | CLOSPI_01749 | CLOSPI_00214 | Pseudouridine synthase, RluA family; KEGG: baa:BA_1831 2.2e-49 PseudoU_synth_2, RNA pseudouridylate synthase K06180; COG: COG0564 Pseudouridylate synthases, 23S RNA-specific. | Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.623 |
| EDS74167.1 | rplO | CLOSPI_01749 | CLOSPI_01588 | Pseudouridine synthase, RluA family; KEGG: baa:BA_1831 2.2e-49 PseudoU_synth_2, RNA pseudouridylate synthase K06180; COG: COG0564 Pseudouridylate synthases, 23S RNA-specific. | Ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. | 0.583 |
| EDS74167.1 | rplQ | CLOSPI_01749 | CLOSPI_01596 | Pseudouridine synthase, RluA family; KEGG: baa:BA_1831 2.2e-49 PseudoU_synth_2, RNA pseudouridylate synthase K06180; COG: COG0564 Pseudouridylate synthases, 23S RNA-specific. | COG: COG0203 Ribosomal protein L17; Psort location: Cytoplasmic, score: 8.87. | 0.591 |
| EDS74167.1 | rplT | CLOSPI_01749 | CLOSPI_00539 | Pseudouridine synthase, RluA family; KEGG: baa:BA_1831 2.2e-49 PseudoU_synth_2, RNA pseudouridylate synthase K06180; COG: COG0564 Pseudouridylate synthases, 23S RNA-specific. | Ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. | 0.583 |
| EDS74167.1 | rplU | CLOSPI_01749 | CLOSPI_00884 | Pseudouridine synthase, RluA family; KEGG: baa:BA_1831 2.2e-49 PseudoU_synth_2, RNA pseudouridylate synthase K06180; COG: COG0564 Pseudouridylate synthases, 23S RNA-specific. | Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. | 0.588 |
| EDS74167.1 | rsfS | CLOSPI_01749 | CLOSPI_01241 | Pseudouridine synthase, RluA family; KEGG: baa:BA_1831 2.2e-49 PseudoU_synth_2, RNA pseudouridylate synthase K06180; COG: COG0564 Pseudouridylate synthases, 23S RNA-specific. | Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.594 |
| EDS74616.1 | EDS74167.1 | CLOSPI_01671 | CLOSPI_01749 | RNA methyltransferase, TrmH family, group 3; KEGG: lin:lin0273 1.4e-61 putative tRNA/rRNA methyltransferase K03218; COG: COG0566 rRNA methylases; Psort location: Cytoplasmic, score: 8.87; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Pseudouridine synthase, RluA family; KEGG: baa:BA_1831 2.2e-49 PseudoU_synth_2, RNA pseudouridylate synthase K06180; COG: COG0564 Pseudouridylate synthases, 23S RNA-specific. | 0.606 |
| EDS74616.1 | cgtA | CLOSPI_01671 | CLOSPI_00881 | RNA methyltransferase, TrmH family, group 3; KEGG: lin:lin0273 1.4e-61 putative tRNA/rRNA methyltransferase K03218; COG: COG0566 rRNA methylases; Psort location: Cytoplasmic, score: 8.87; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Obg family GTPase CgtA; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 0.488 |
| EDS74616.1 | hflB | CLOSPI_01671 | CLOSPI_02241 | RNA methyltransferase, TrmH family, group 3; KEGG: lin:lin0273 1.4e-61 putative tRNA/rRNA methyltransferase K03218; COG: COG0566 rRNA methylases; Psort location: Cytoplasmic, score: 8.87; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | ATP-dependent metallopeptidase HflB; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.418 |
| EDS74616.1 | rplC | CLOSPI_01671 | CLOSPI_01569 | RNA methyltransferase, TrmH family, group 3; KEGG: lin:lin0273 1.4e-61 putative tRNA/rRNA methyltransferase K03218; COG: COG0566 rRNA methylases; Psort location: Cytoplasmic, score: 8.87; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | 50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | 0.745 |
| EDS74616.1 | rplM | CLOSPI_01671 | CLOSPI_00214 | RNA methyltransferase, TrmH family, group 3; KEGG: lin:lin0273 1.4e-61 putative tRNA/rRNA methyltransferase K03218; COG: COG0566 rRNA methylases; Psort location: Cytoplasmic, score: 8.87; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.796 |
| EDS74616.1 | rplO | CLOSPI_01671 | CLOSPI_01588 | RNA methyltransferase, TrmH family, group 3; KEGG: lin:lin0273 1.4e-61 putative tRNA/rRNA methyltransferase K03218; COG: COG0566 rRNA methylases; Psort location: Cytoplasmic, score: 8.87; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. | 0.736 |
| EDS74616.1 | rplQ | CLOSPI_01671 | CLOSPI_01596 | RNA methyltransferase, TrmH family, group 3; KEGG: lin:lin0273 1.4e-61 putative tRNA/rRNA methyltransferase K03218; COG: COG0566 rRNA methylases; Psort location: Cytoplasmic, score: 8.87; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | COG: COG0203 Ribosomal protein L17; Psort location: Cytoplasmic, score: 8.87. | 0.732 |
| EDS74616.1 | rplT | CLOSPI_01671 | CLOSPI_00539 | RNA methyltransferase, TrmH family, group 3; KEGG: lin:lin0273 1.4e-61 putative tRNA/rRNA methyltransferase K03218; COG: COG0566 rRNA methylases; Psort location: Cytoplasmic, score: 8.87; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. | 0.597 |
| EDS74616.1 | rplU | CLOSPI_01671 | CLOSPI_00884 | RNA methyltransferase, TrmH family, group 3; KEGG: lin:lin0273 1.4e-61 putative tRNA/rRNA methyltransferase K03218; COG: COG0566 rRNA methylases; Psort location: Cytoplasmic, score: 8.87; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. | 0.730 |
| EDS74616.1 | rsfS | CLOSPI_01671 | CLOSPI_01241 | RNA methyltransferase, TrmH family, group 3; KEGG: lin:lin0273 1.4e-61 putative tRNA/rRNA methyltransferase K03218; COG: COG0566 rRNA methylases; Psort location: Cytoplasmic, score: 8.87; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.728 |
