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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (165 aa)    
Predicted Functional Partners:
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
 
 0.999
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
 0.999
EDS74218.1
Chorismate mutase; KEGG: aae:aq_951 3.3e-53 pheA; chorismate mutase/prephenate dehydratase K04093:K04518; COG: COG0077 Prephenate dehydratase; Psort location: Cytoplasmic, score: 9.98.
 
 0.996
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
 
 0.983
EDS75892.1
Putative shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
 
 0.981
aroD
3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family.
  
 0.922
aroF-2
3-deoxy-7-phosphoheptulonate synthase; KEGG: cac:CAC0892 6.4e-114 phospho-2-dehydro-3-deoxyheptonate aldolase K03856; COG: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.867
EDS75227.1
KEGG: cno:NT01CX_0626 1.1e-70 prephenate dehydrogenase K00210; COG: COG0287 Prephenate dehydrogenase; Psort location: Cytoplasmic, score: 8.87.
 
 
 0.862
cmk
Cytidylate kinase; KEGG: bca:BCE_1623 2.5e-55 cmk; cytidylate kinase K00945; COG: COG0283 Cytidylate kinase; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.612
aroF
3-deoxy-7-phosphoheptulonate synthase; KEGG: cac:CAC0892 5.7e-113 phospho-2-dehydro-3-deoxyheptonate aldolase K03856; COG: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.547
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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