STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
lepB-2Signal peptidase I; KEGG: ctc:CTC01253 9.3e-26 putative signal peptidase I K03100; COG: COG0681 Signal peptidase I; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the peptidase S26 family. (171 aa)    
Predicted Functional Partners:
lepB
KEGG: bce:BC3837 2.5e-32 signal peptidase I K03100; COG: COG0681 Signal peptidase I; Belongs to the peptidase S26 family.
  
  
 
0.918
lepA
GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.
  
 
 0.698
sigF
KEGG: hpa:HPAG1_0089 4.4e-23 RNA polymerase sigma-80 factor K00960; COG: COG1191 DNA-directed RNA polymerase specialized sigma subunit; Psort location: Cytoplasmic, score: 9.98; Belongs to the sigma-70 factor family.
     
 0.671
EDS74307.1
Hypothetical protein.
       0.661
EDS74309.1
STAS domain protein; KEGG: msu:MS1346 0.0064 hemH; protoheme ferro-lyase (ferrochelatase) K01772; COG: COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor); Belongs to the anti-sigma-factor antagonist family.
       0.661
spoIIAB
Anti-sigma F factor; KEGG: cpr:CPR_2021 9.4e-33 spoIIAB; anti-sigma F factor K06379; COG: COG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase); Psort location: Cytoplasmic, score: 8.87.
       0.661
EDS74308.1
Serine-type D-Ala-D-Ala carboxypeptidase; KEGG: gka:GK2311 1.9e-82 D-alanyl-D-alanine carboxypeptidase (penicilin binding protein) K01286; COG: COG1686 D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family.
 
  
 0.592
EDS75817.1
Class II glutamine amidotransferase; KEGG: syn:sll1502 0. gltB; NADH-dependent glutamate synthase large subunit K00268; COG: COG0069 Glutamate synthase domain 2; Psort location: Cytoplasmic, score: 8.87.
     
 0.576
EDS74313.1
Hypothetical protein; Psort location: Cytoplasmic, score: 8.87.
       0.574
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.564
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.