STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDS74495.1Sigma-70 region 2; KEGG: bcz:BCZK3297 5.0e-11 RNA polymerase ECF-type sigma factor K03088; COG: COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (160 aa)    
Predicted Functional Partners:
EDS74496.1
Hypothetical protein; COG: NOG16911 non supervised orthologous group.
   
 0.966
EDS74494.1
Hypothetical protein; KEGG: ddi:DDB0190008 0.00012 hypothetical protein K01230; COG: KOG2798 Putative trehalase.
       0.741
rpoC
DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.726
rpoB
DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.708
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.658
EDS75520.1
Kinase domain protein; KEGG: lmo:lmo1820 5.3e-110 similar to putative serine/threonine-specific protein kinase K08884; COG: COG2815 Uncharacterized protein conserved in bacteria; Psort location: CytoplasmicMembrane, score: 9.49.
   
 
 0.571
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 
 0.564
EDS75242.1
Transcriptional regulator, PadR family; COG: COG1695 Predicted transcriptional regulators; Psort location: Cytoplasmic, score: 8.87.
  
    0.549
EDS75633.1
Hypothetical protein; KEGG: pfa:PFI0960w 0.0016 dolichyl-diphosphooligosaccharide--protein-glyco transferase,putative K00730; COG: COG2770 FOG: HAMP domain.
   
   0.530
EDS75400.1
KEGG: tcx:Tcr_1209 8.0e-07 exodeoxyribonuclease VII, large subunit K03601; COG: NOG21997 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87.
   
   0.530
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.