STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hptKEGG: spn:SP_0012 2.4e-50 hypoxanthine-guanine phosphoribosyltransferase K00760; COG: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Psort location: Cytoplasmic, score: 9.98; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (176 aa)    
Predicted Functional Partners:
tilS
tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.
 
  
 0.976
hflB
ATP-dependent metallopeptidase HflB; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
  
  
 0.975
guaA
GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP.
  
 
 0.958
purA
Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.947
xpt
Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
  
 0.942
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
   
 
 0.941
EDS74818.1
KEGG: lmf:LMOf2365_0150 3.1e-215 inosine-5'-monophosphate dehydrogenase, putative K00088; COG: COG0516 IMP dehydrogenase/GMP reductase; Psort location: Cytoplasmic, score: 8.87.
    
 0.940
purH
KEGG: cpf:CPF_0677 2.0e-133 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase K00602:K01492; COG: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); Psort location: Cytoplasmic, score: 8.87.
  
 
 0.939
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
 
  
 0.932
EDS75509.1
Conserved hypothetical protein, YfiH family; COG: COG1496 Uncharacterized conserved protein; Belongs to the multicopper oxidase YfiH/RL5 family.
  
 
  0.912
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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