STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nrdD-2KEGG: ssn:SSO_4419 1.6e-126 nrdD; anaerobic ribonucleoside-triphosphate reductase K00527; COG: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; Psort location: Cytoplasmic, score: 8.87. (719 aa)    
Predicted Functional Partners:
nrdG-2
Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
 
 
 0.988
nrdD
KEGG: pac:PPA2137 8.7e-236 anaerobic ribonucleoside triphosphate reductase K00527; COG: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; Psort location: Cytoplasmic, score: 8.87.
  
  
 
0.915
dut
dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
    
 0.915
pyrG
CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
     
 0.906
EDS75148.1
RelA/SpoT family protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
     
 0.903
EDS74647.1
Hypothetical protein; COG: COG1618 Predicted nucleotide kinase.
   
 
  0.903
maf
Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
    
  0.900
EDS74115.1
Putative dGTPase; KEGG: pcu:pc0465 4.6e-47 dgt; putative deoxyguanosinetriphosphate triphosphohydrolase (dGTPase) K01129; COG: COG0232 dGTP triphosphohydrolase; Psort location: Cytoplasmic, score: 8.87.
    
  0.900
EDS73965.1
RelA/SpoT domain protein; KEGG: lpl:lp_0293 1.2e-34 GTP pyrophosphokinase (putative) K00951; COG: COG2357 Uncharacterized protein conserved in bacteria; Psort location: Cytoplasmic, score: 8.87.
     
  0.900
EDS74018.1
RelA/SpoT domain protein; KEGG: btk:BT9727_4080 2.3e-38 probable GTP diphosphokinase (GTP pyrophosphokinase) K00951; COG: COG2357 Uncharacterized protein conserved in bacteria; Psort location: Cytoplasmic, score: 8.87.
     
  0.900
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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