Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
EDS73844.1ParB-like protein; KEGG: pub:SAR11_0354 6.1e-38 parB; chromosome partitioning protein K03497; COG: COG1475 Predicted transcriptional regulators; Psort location: Cytoplasmic, score: 8.87; Belongs to the ParB family. (255 aa)    
Predicted Functional Partners:
soj
Sporulation initiation inhibitor protein Soj; KEGG: cch:Cag_1803 4.4e-67 ATPase, ParA family K03496; COG: COG1192 ATPases involved in chromosome partitioning; Psort location: Cytoplasmic, score: 8.87.
 
 0.991
gidB
16S rRNA methyltransferase GidB; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
  
  
 0.935
gidA
tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family.
  
  
 0.823
EDS75004.1
FtsK/SpoIIIE family protein; KEGG: pen:PSEEN2212 1.2e-101 ftsK; cell division protein FtsK; COG: COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins; Psort location: CytoplasmicMembrane, score: 9.99.
  
  
 0.738
EDS73828.1
ParB-like protein; KEGG: pub:SAR11_0354 4.2e-46 parB; chromosome partitioning protein K03497; COG: COG1475 Predicted transcriptional regulators; Psort location: Cytoplasmic, score: 8.87; Belongs to the ParB family.
 
   
0.621
dnaA
Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family.
 
  
 0.564
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.557
EDS73847.1
Hypothetical protein; KEGG: cpv:cgd7_440 0.00019 RIO-like kinase domain; N-terminal region conserved K07179; COG: KOG1181 FOG: Low-complexity; Psort location: Cytoplasmic, score: 8.87.
       0.506
guaA
GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP.
     
 0.456
greA
Prokaryotic transcription elongation factor, GreA/GreB domain protein; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
  
 
 
 0.400
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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