node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EDP10467.1 | EDP10586.1 | EUBDOL_01711 | EUBDOL_01837 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | DnaJ domain protein; KEGG: cme:CMJ043C 8.1e-05 phycocyanobilin lyase alpha subunit K02288; COG: COG2214 DnaJ-class molecular chaperone; Psort location: Cytoplasmic, score:9.65. | 0.486 |
EDP10467.1 | EDP11538.1 | EUBDOL_01711 | EUBDOL_00716 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | LPXTG-motif cell wall anchor domain protein; KEGG: bme:BMEII0148 5.9e-10 extracellular serine protease; COG: COG3468 Type V secretory pathway, adhesin AidA; Psort location: Cellwall, score:9.91. | 0.486 |
EDP10467.1 | clpP | EUBDOL_01711 | EUBDOL_02287 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Endopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.450 |
EDP10467.1 | dnaJ | EUBDOL_01711 | EUBDOL_01830 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.486 |
EDP10467.1 | dnaK | EUBDOL_01711 | EUBDOL_01829 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.452 |
EDP10467.1 | groL | EUBDOL_01711 | EUBDOL_02217 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.463 |
EDP10467.1 | grpE | EUBDOL_01711 | EUBDOL_01828 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.771 |
EDP10586.1 | EDP10467.1 | EUBDOL_01837 | EUBDOL_01711 | DnaJ domain protein; KEGG: cme:CMJ043C 8.1e-05 phycocyanobilin lyase alpha subunit K02288; COG: COG2214 DnaJ-class molecular chaperone; Psort location: Cytoplasmic, score:9.65. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.486 |
EDP10586.1 | clpP | EUBDOL_01837 | EUBDOL_02287 | DnaJ domain protein; KEGG: cme:CMJ043C 8.1e-05 phycocyanobilin lyase alpha subunit K02288; COG: COG2214 DnaJ-class molecular chaperone; Psort location: Cytoplasmic, score:9.65. | Endopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.641 |
EDP10586.1 | dnaK | EUBDOL_01837 | EUBDOL_01829 | DnaJ domain protein; KEGG: cme:CMJ043C 8.1e-05 phycocyanobilin lyase alpha subunit K02288; COG: COG2214 DnaJ-class molecular chaperone; Psort location: Cytoplasmic, score:9.65. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.998 |
EDP10586.1 | groL | EUBDOL_01837 | EUBDOL_02217 | DnaJ domain protein; KEGG: cme:CMJ043C 8.1e-05 phycocyanobilin lyase alpha subunit K02288; COG: COG2214 DnaJ-class molecular chaperone; Psort location: Cytoplasmic, score:9.65. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.832 |
EDP10586.1 | groS | EUBDOL_01837 | EUBDOL_02216 | DnaJ domain protein; KEGG: cme:CMJ043C 8.1e-05 phycocyanobilin lyase alpha subunit K02288; COG: COG2214 DnaJ-class molecular chaperone; Psort location: Cytoplasmic, score:9.65. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.717 |
EDP10586.1 | grpE | EUBDOL_01837 | EUBDOL_01828 | DnaJ domain protein; KEGG: cme:CMJ043C 8.1e-05 phycocyanobilin lyase alpha subunit K02288; COG: COG2214 DnaJ-class molecular chaperone; Psort location: Cytoplasmic, score:9.65. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.968 |
EDP10586.1 | hrcA | EUBDOL_01837 | EUBDOL_01827 | DnaJ domain protein; KEGG: cme:CMJ043C 8.1e-05 phycocyanobilin lyase alpha subunit K02288; COG: COG2214 DnaJ-class molecular chaperone; Psort location: Cytoplasmic, score:9.65. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.689 |
EDP10586.1 | msrA | EUBDOL_01837 | EUBDOL_00958 | DnaJ domain protein; KEGG: cme:CMJ043C 8.1e-05 phycocyanobilin lyase alpha subunit K02288; COG: COG2214 DnaJ-class molecular chaperone; Psort location: Cytoplasmic, score:9.65. | Peptide-methionine (S)-S-oxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.554 |
EDP11538.1 | EDP10467.1 | EUBDOL_00716 | EUBDOL_01711 | LPXTG-motif cell wall anchor domain protein; KEGG: bme:BMEII0148 5.9e-10 extracellular serine protease; COG: COG3468 Type V secretory pathway, adhesin AidA; Psort location: Cellwall, score:9.91. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.486 |
EDP11538.1 | clpP | EUBDOL_00716 | EUBDOL_02287 | LPXTG-motif cell wall anchor domain protein; KEGG: bme:BMEII0148 5.9e-10 extracellular serine protease; COG: COG3468 Type V secretory pathway, adhesin AidA; Psort location: Cellwall, score:9.91. | Endopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.633 |
EDP11538.1 | dnaK | EUBDOL_00716 | EUBDOL_01829 | LPXTG-motif cell wall anchor domain protein; KEGG: bme:BMEII0148 5.9e-10 extracellular serine protease; COG: COG3468 Type V secretory pathway, adhesin AidA; Psort location: Cellwall, score:9.91. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.991 |
EDP11538.1 | groL | EUBDOL_00716 | EUBDOL_02217 | LPXTG-motif cell wall anchor domain protein; KEGG: bme:BMEII0148 5.9e-10 extracellular serine protease; COG: COG3468 Type V secretory pathway, adhesin AidA; Psort location: Cellwall, score:9.91. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.803 |
EDP11538.1 | groS | EUBDOL_00716 | EUBDOL_02216 | LPXTG-motif cell wall anchor domain protein; KEGG: bme:BMEII0148 5.9e-10 extracellular serine protease; COG: COG3468 Type V secretory pathway, adhesin AidA; Psort location: Cellwall, score:9.91. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.710 |