STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDP10096.1KEGG: lin:lin0179 1.4e-214 similar to inosine monophosphate dehydrogenase K00088; COG: COG0517 FOG: CBS domain; Psort location: Cytoplasmic, score:8.87. (503 aa)    
Predicted Functional Partners:
guaA
GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP.
 0.999
guaA-2
GMP synthase (glutamine-hydrolyzing) domain protein; KEGG: bth:BT2419 8.9e-179 putative GMP synthase [glutamine-hydrolyzing] K01951; COG: COG0518 GMP synthase - Glutamine amidotransferase domain; Psort location: Cytoplasmic, score:8.87.
 0.999
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: bsu:BG10710 1.3e-177 purH, purJ, purHJ; phosphoribosylaminoimidazole carboxy formyl formyltransferase / inosine-monophosphate cyclohydrolase K00602:K01492; COG: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); Psort location: Cytoplasmic, score:8.87.
  
 
 0.973
EDP11421.1
CBS domain protein; KEGG: afu:AF0847 1.7e-10 guaB-1; IMP dehydrogenase K00088; COG: COG0517 FOG: CBS domain.
  
 
 0.962
EDP11208.1
5'-nucleotidase; KEGG: dps:DP1354 3.8e-84 similar to 5'-nucleotidase K01081; COG: NOG04570 non supervised orthologous group.
     
  0.953
rdgB
Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
 0.952
EDP11700.1
DHHA2 domain protein; KEGG: ctc:CTC01649 2.0e-94 putative manganese-dependent inorganic pyrophosphatase K01507; COG: COG1227 Inorganic pyrophosphatase/exopolyphosphatase; Psort location: Cytoplasmic, score:8.87.
  
 
 0.942
xpt
Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
  
 
 0.939
hpt
Hypoxanthine phosphoribosyltransferase; KEGG: lla:L25115 1.9e-50 hpt; hypoxantine-guanine phosphorybosyltransferase K00760; COG: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Psort location: Cytoplasmic, score:9.98; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
    
 0.932
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 
 0.913
Your Current Organism:
Absiella dolichum
NCBI taxonomy Id: 428127
Other names: A. dolichum DSM 3991, Absiella dolichum ATCC 29143, Absiella dolichum DSM 3991, Eubacterium dolichum ATCC 29143, Eubacterium dolichum DSM 3991, Eubacterium dolichum strain DSM 3991
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